New podcast up! The Inflammation Reflex Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv. This week, neuroimmunology leading to therapy, the cold shoulder approach and Regulatory updates from the FDA.https://t.co/9LyiTmiPNJ https://t.co/tHJuEfDhd6

New podcast up! The Inflammation Reflex Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv. This week, neuroimmunology leading to therapy, the cold shoulder approach and Regulatory updates from the FDA.https://t.co/9LyiTmiPNJ https://t.co/tHJuEfDhd6

Wiki Guidelines Approach to Pyogenic Osteomyelitishttps://t.co/4HD60dbPkk https://t.co/t4xHSWKXys

Data from Scleroderma Lung Study (CTX vs MMF in PSS) shows that early progression of ILD by CXR scoring (≥ 2% at 12 or 24 months) experienced significantly worse long-term survival than those with stable Xrays (P = .014). https://t.co/hv2WNJ4Chr https://t.co/W5RIhoIGtT

Multimorbidity Burden in Rheumatoid Arthritis Crowson and colleagues at the Mayo Clinic have shown that rheumatoid arthritis (RA) patients have a higher prevalence of multimorbidity with as many as 44 different morbidities of interest in RA.https://t.co/O5U6VXalwa https://t.co/BzXyMGz0ms

Many have quoted and shown this image of Ankylosing Spondylitis in a young military recruit at age 25, 35, 45, 50 & 51yrs. This may be the MOST used slide in rheum! It comes from the work of Toronto's Dr. Hugh Little, who sadly passed away at age 58 yrs. https://t.co/e3Zf1OUqtX https://t.co/zOhnQf3ep9

Rising Incidence of Systemic Lupus Erythematosus Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing.https://t.co/GUakRwwWQw https://t.co/LPnVMTT8Ro

Join us on May 24 at 7pm for Tuesday Night Rheumatology: RA - Best Management We’ll focus on: Drug Cycling Vs Switching in RA Janet Pope, MD, MPH, FRCPC Multimorbidity in RA Elena Myasoedova, MD, PhD Preventing RA Karen Costenbader, MDhttps://t.co/Vc5uECptIo https://t.co/fu3qACdHkL

The Inflammation Reflex (5.20.2022)

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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week, neuroimmunology leading to therapy, the cold shoulder approach and Regulatory updates from the FDA.

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Watch: The Music of Rheumatology with Dr. Ronan Kavanagh What does music have to do with rheumatology? Quite a lot, actually.https://t.co/R9n0vEYB2J https://t.co/M8Jpg1g6QI

Relevance of Raynaud’s in Systemic Sclerosis A recent analysis suggests that RP should be characterized based on color change and the presence of other symptoms to know whether RP portends more serious manifestations.https://t.co/rLo6Ju5LV1 https://t.co/gAQAYxe9rL

Israel study of 171 kids w/ MIS-C (med age 8 (5-12): Dx#s - 59 during Alpha , 79 Delta , & 33 Omicron waves. All Rx w/ IVIG + steroids. 6-15% prev recv COVID VAX, none ICU admitted. Worse Dz & higher incidence during alpha wave (54.5/100K) https://t.co/wAby8uKIH4 https://t.co/zc19zeUKpq

From 4 Nordic Registries, 24083 RA patients starting 41K courses of bDMARDs shows RA patients had an 80% higher risk of acute coronary syndromes than in the general population. ACS risk on bDMARDs did not improve at 3yrs or 5 yrs https://t.co/TX3jnIXkrW https://t.co/I34UvWH3qd

Ontario population study shows that musculoskeletal disorders account for 12.3% of all adult emergency dept. visits and 28.5% outpatient physician visits https://t.co/Sq9n7RkIYK https://t.co/lKtQqR5Ja3

Watch: The Almighty ANA Dr. Lipsky discussed how our thinking and use of ANA and serologic testing has evolved and is crucial to outcomes and trials in his lecture, The Almighty ANA, presented during the at #RNL2022 in March. #lupushttps://t.co/Xxxj18badY https://t.co/5pwV4xSGDx

Biologic Persistence in Psoriatic Arthritis and Psoriasis

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Two recent studies examined the durability and persistence of biologic agents in patients with psoriasis (PSO) and psoriatic arthritis (PsA) and while some differences were noted overall persistence was low 3 years later.

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Inflammatory Arthritis Spread by ATP and Neural Crosstalk

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A novel study from the Journal of Experimental Medicine suggests that a reflex neural signaling at sites of inflammation may lead to spread to other inflammatory sites via and ATP-mediated neural crosstalk.

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Local cryotherapy in adjuvant-induced arthritis in rats given bid resulted in lower arthritis scores, structural damages, less vascular inflammation/endothelial activation (less mRNA CXCL-1, IL-6, IL-1β, leukocyte infiltration, lower IL-17A and OPG https://t.co/b4cAa9E4PJ https://t.co/vhwWoY8Ujw

RCT (WBC) whole body cryotherapy (-130C x 3 min; 6 WBC in 14 d) in 56 RA pts. Pain at 2 wks was signif better in WBC than controls (-2 vs -0.88 ; p=0.003) & remained lower x 12 weeks (w less pain meds); Dz activity & Function improved but not signif @wk 12 https://t.co/K7a7CQ7rGj https://t.co/a8QgiDeJS6

Many have quoted and shown this image of Ankylosing Spondylitis in a young military recruit at age 25, 35, 45, 50 & 51yrs. This may be the MOST used slide in rheum! It comes from the work of Toronto's Dr. Hugh Little, who sadly passed away at age 58 yrs. https://t.co/PGrwBEtrQd https://t.co/948G3SUHvV