Novel Proteomic Biomarker Set in Osteoarthritis

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NIH funded researchers from Duke University have developed a set of serum proteomic biomarkers that successfully predict clinically relevant knee osteoarthritis (KOA) progression (both structural change and joint pain) over a 2 year period.

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Blood Test Identifies Osteoarthritis Progression A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies. https://t.co/hOAjxJhnJG https://t.co/Ehr5imPNQ4

Blood Test Identifies Osteoarthritis Progression

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A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies.

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Burden of BMI on Costs of Musculoskeletal Diseases

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A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.

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New Hope for Hand Osteoarthritis The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis. https://t.co/AHoEZM75mh https://t.co/dZ1LWWoNl5

Degeneration seen in #OA may be related to cartilage tissue stiffening with the repression of a key longevity protein α-Klotho brought about by epigenetic changes. Downregulated Klotho gene expression accelerated chondrocyte senescence https://t.co/HBLeLIlmJG https://t.co/T7d6EodDYN

Network meta-analysis of 152 RCTs (17431 pts) comparing efficacy of exercise therapy, NSAIDs, Tylenol for knee or hip osteoarthritis: Found all 3 equivalent at 4 wk, 8 wk and 24 wks. https://t.co/rKck2AacL4 https://t.co/YEAMh9UxTs

Cannabis Use for Pain is Common

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In states with legalized medical cannabis use, 3 in 10 persons are using cannabis to manage their pain.

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Extreme Global Costs of Physical Inactivity

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A global, population-based study shows that physical inactivity is not only an important modifiable risk factor for non-communicable diseases (NCDs) and mental health conditions, it also imparts a considerable health and economic burden that is avoidable.

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Hyaluronic Acid Knee Injections Equivalent to Placebo In the United States, where over $300 million is spent annually on intraarticular hyaluronic acid injections, yet another study shows such therapy to be no better than placebo.https://t.co/bBEwpId84L https://t.co/5msGqViTpz

Effect of Intraarticular Steroid Shots on Knee OA Outcomes In patients with osteoarthritis of the knee, intra-articular injections of steroids did not increase rates of either disease progression or subsequent knee replacement surgery, researchers said.https://t.co/yqVHPmqzzi https://t.co/k8dMADHg7P

New Hope for Hand Osteoarthritis The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.https://t.co/jVMLiJLnch https://t.co/0nk8WA2k1S

New Hope for Hand Osteoarthritis

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The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.

Read Article

Metformin Reduces Osteoarthritis Risk in NIDDM Patients

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Osteoarthritis is a common chronic condition that usually causes joint pain and can be severe enough to require knee and hip replacements. In the United States, the number of total knee replacement (TKR) and total hip replacement (THR) surgeries is estimated to reach 572 000 per year by 2030.

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Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work?https://t.co/s4Gzmh2gGZ https://t.co/aZORTMtCvs

#OA phenotypes by SF cell status - Activated: hi T-cell, low mono–macrop-PMN activated; 70% improved - Lymphoid: hi PMN, low lymph & mono, low activ, lower pain - Myeloid: hi NK & mono, low T-cell & activat - Aggressive: hi lymph/macr/NK/PMN;39%improve -https://t.co/3DXPoDE5Pm https://t.co/VRJkscAm5a

Multi-ancestry analysis reveals novel genetic loci associated with Osteoarthritis

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The first large multi-ancestry genetics study of osteoarthritis (OA) has found 10 novel OA-associated genetic loci, and results showed some of the OA-associated regions are robustly found in every population ancestry studied. 

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In pts undergoing hip or knee arthroplasty for OA, aspirin (3.45%) compared with enoxaparin (1.82%) resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism https://t.co/7hgLbynNx6 https://t.co/HMc4UbMcdy

Steroid injections worsen knee arthritis Two studies comparing injections commonly used to relieve the pain of knee osteoarthritis found that corticosteroid injections were associated with the progression of the disease. https://t.co/pAeU3IzZfx https://t.co/rgJeHM5t62

How Underweight Women Can Reduce Hip Fracture Risk

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How women can reduce the risk of hip fracture?  

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