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TNF Inhibitors or non-TNF Biologics - First Best Choice?

Jack Cush, MD
Oct 18, 2020

Prospective observational findings from the CORRONA registry of rheumatoid arthritis (RA) patients compared clinical outcomes between initial aggressive therapy using either a tumour necrosis factor inhibitor (TNFi) or a non-TNFi (biological disease-modifying antirheumatic drugs (bDMARDs) and tar

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RheumNow Podcast – Good Time Charlie…. (10.16.20)

Jack Cush, MD
Oct 15, 2020

Dr. Jack Cush sings the news and journal reports from the past week on RheumNow.com.

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Nonradiographic axial spondyloarthritis= meeting axSpA criteria without Xray sacroiliitis. Swiss study compared women & men w nr-axSpA.

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Dr. John Cush RheumNow ( View Tweet)

Oct 12, 2020
The RheumNow Podcast is up - Bad Disease & Bad Outcomes. COVID consequences, TNFi Switching in SpA, psychosis in lupus?

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Dr. John Cush RheumNow ( View Tweet)

Oct 11, 2020
The RheumNow Podcast is up - Bad Disease & Bad Outcomes. COVID consequences, TNFi Switching in SpA, psychosis in lupus?

Links:

Dr. John Cush RheumNow ( View Tweet)

Oct 11, 2020
The RheumNow Podcast is up - Bad Disease & Bad Outcomes. COVID consequences, TNFi Switching in SpA, psychosis in lupus?

Links:

Dr. John Cush RheumNow ( View Tweet)

Oct 11, 2020
Study of 193 Axial SpA pts with TNF inhibitor switching shows, using stringent outcome measures (ASDAS-ID) shows odds of responding to 2nd TNFi best w/ secondary TNFi failure (OR 7.3) or adverse events (OR 9.1), compared to primary TNFi failure.

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Dr. John Cush RheumNow ( View Tweet)

Oct 08, 2020
Incredible lecture on the highest of therapeutics for rheumatoid arthritis by @BrighamWomens Dr Michael Weinblatt. Love this screen shot of A to Z for therapies prior to the methotrexate era. Z=Zero therapy (do nothing). Incredible advances since then!
Jeff Sparks jeffsparks ( View Tweet)
Oct 06, 2020
ASSERT looked at ankylosing spondylitis (AS) pts treated with infliximab (n = 16) or placebo (n = 7). Infliximab was shown to reduce depression & depressive symptoms by improving AS disease Sxs.

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Dr. John Cush RheumNow ( View Tweet)

Sep 29, 2020
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EULAR Updated 2019 Recommendations for Psoriatic Arthritis Management

Jack Cush, MD
Sep 24, 2020

In June 2020, we failed to report on the ARD publication updating the 2019 update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA) - these are presented below.

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RheumNow Podcast – Lupus Delights (9.18.20)

Jack Cush, MD
Sep 18, 2020

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

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Retrospective cohort study of 213 IMID patients, 36.2% tested positive for COVID-19, who had no greater risk of hospitalized or ventilation and immunosuppressive use was not shown to worsened the course of disease (TNFi decreased risk of hospitalization) https://t.c

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Dr. John Cush RheumNow ( View Tweet)

Sep 16, 2020
Discontinuing TNFi before wk 20 is feasible in RA and JIA pregnancy with well- controlled Dz. OTIS study of 490 women compared 25% who D/C TNFi before wk 20 vs 41% taking TNFi after wk 20. D/C TNF not assoc w/ clinical worsening in the 3rd trimester.

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Dr. John Cush RheumNow ( View Tweet)

Sep 12, 2020
Systematic review of Paternal DMARD exposure prior to pregnancy shows no firm evidence of harm with TNFi, ABA, RTX, azathioprine, cyclosporine, HCQ, leflunomide, MTX or mycophenolate mofetil.

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Dr. John Cush RheumNow ( View Tweet)

Sep 11, 2020
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ICYMI - 11 Pearls for Pregnancy Management in Rheumatoid Arthritis

Artie Kavanaugh, MD
Sep 09, 2020

Rheumatoid arthritis affects women in their child-bearing years and many will face the issue of pregnancy and RA management at some point. Here are11 considerations for those managing RA patients who wish to become pregnant.



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RheumNow Podcast – To Celiac Test or Not? (9.4.20)

Jack Cush, MD
Sep 04, 2020

Dr Jack Cush reviews the news, journal articles and takes a few Back Talk questions this week:

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RheumNow Podcast is Up! Rheum Lives Matter. More about social change, HCQ, JAKs & skin, growing cartilage, FM exercise. Watch it here>https://t.co/LLvADsDJ5O or listen to the Podcast here>https://t.co/pCXzaJUS9s

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Dr. John Cush RheumNow ( View Tweet)

Aug 29, 2020
RheumNow Podcast is Up! Rheum Lives Matter. More about social change, HCQ, JAKs & skin, growing cartilage, FM exercise. Watch it here>https://t.co/LLvADsDJ5O or listen to the Podcast here>https://t.co/pCXzaJUS9s

Links:

Dr. John Cush RheumNow ( View Tweet)

Aug 29, 2020
UK safety reminder that Baricitinib (Olumiant) has an increased risk of diverticulitis (incidence rate 0.16 per 100PY), esp. in those taking Steroids or NSAIDs. https://t.co/IfcV03e1p7

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Dr. John Cush RheumNow ( View Tweet)

Aug 28, 2020
Mayo case controlled study of 212 autoimmune pts - half w/ CNS inflamm dz and half without.

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Dr. John Cush RheumNow ( View Tweet)

Aug 24, 2020

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