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Autoimmune Disease Augments Cardiovascular Risk

Aug 29, 2022 3:45 pm

A large UK database study suggests that young adults with autoimmune diseases have an associated increased risk for cardiovascular disease.

A population-based study examined 22,009,375 persons from the Clinical Practice Research Datalink (CPRD), GOLD and Aurum datasets.  This included a subset with newly diagnosed, 19 autoimmune diseases (n=446 449) and over 2.1 million matched controls seen between 2000 and 2017. They included those under age 80 years without a cardiovascular disease in the prior 12 months.

Autoimmune cohort were 61% were women.  After a median of 6.2 years followup, cardiovascular disease was more likely in the autoimmune patients (15·3%) that those without AID (11%). This translates to a CVD incidence rate of 23.3 events per 1000 patient-years (compared to 15 events per 1000 patient-years) with a higher risk among those with an autoimmune disease (hazard ratio 1.56; CI 1·52–1·59).

CV disease risk was increased moreso in younger age groups (age <45 years: HR 2·33) compared to ages 55–64 years (HR 1·76) and ≥75 years (HR 1·30). CV risk mounted with increasing numbers of autoimmune disease (one disease: HR 1·41; two diseases: HR 2·63; three or more HR 3·79 [3·36–4·27].

CV risk was highest with systemic sclerosis (HR 3·59), Addison's disease (HR 2·83), systemic lupus erythematosus (HR 2·82), and type 1 diabetes (HR 2·36).

Screening and cardiovascular prevention measures should be strongly considered in those with autoimmune diseases, especially before age 45 years.


The author has no conflicts of interest to disclose related to this subject

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