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Bidirectional Association Between Depression and Rheumatoid Arthritis

Aug 23, 2022 4:21 pm

A recent meta-analysis suggests a bidirectional association between rheumatoid arthritis (RA) and depression.  Finding RA patients with depression yields an 80% increased mortality risk.

Anti-cytokine therapies represents a potential alternative for the treatment of depression.

Analysis of 11 cohort studies included 39,130 RA patients, 550,782 patients with depression and 7,802,230 controls.

RA patients had a 47% greater risk of incident depression compared to controls.

Depression patients had a 34% greater risk of developing RA, this was only significant in the ≥60 years old age group. RA patients with depression had an 80% increased risk of all-cause mortality compared to those without depression.

This bidirectional association between RA and depression may be more importan in the elderly. This remains a significant comorbidity which rheumatologists generally do no screen for.

The author has no conflicts of interest to disclose related to this subject

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