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Osteonecrosis in Lupus

Jul 15, 2021 12:46 pm

A single center analysis of systemic lupus erythematosus (SLE) patients found symptomatic osteonecrosis (ON) in nearly 10%.

Researchers analyzed data from 912 SLE patients admitted to the hospital (1981 to 2012).  Of these 912 SLE patients, 97 had symptomatic ON with an overall prevalence of 10.6%.

SLE patients with ON tended to be older at diagnosis (34.2 vs 27.9 years) and the interval fromSLE diagnosis to OA onset was a mean of 70.7± 60.2 (range = 0-216) months.

Symptomatic ON most commonly affected the hips (68%), and the knees (38%). Hip and knee joint survival rates were 51% and 88% at 5 years and 43% and 84%, respectively at 10 years.

Symptomatic ON in SLE has poorer outcomes in the hip compared to the knee. 

The author has no conflicts of interest to disclose related to this subject

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