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FDA: New Cardiac and Cancer Warnings for All JAK Inhibitors

Sep 01, 2021

Today, Sept.1st, the FDA announced its findings regarding tofacitinib's safety concerns from the Oral Surveillance study - handing down warnings for not only Pfizer's JAK inhibitor, but also for other marketed JAK inhibitors from AbbVie and Eli Lilly & Co.

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ACR Comments on JAK Inhibitors and FDA Announcement

ACR
Sep 13, 2021

Statement from ACR President David Karp, MD, PhD:

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ACR Guidance on Timing of 3rd Dose Booster with Immunomodulatory Drugs

ACR Press Release
Aug 25, 2021

The American College of Rheumatology has issued an updated version of its COVID-19 Vaccine Clinical Guidance for Patients with Rheumatic and Musculoskeletal Diseases following recent recommendations from the CDC that certain immunocompromised patients receive a third dose of an available mRNA vac

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EULAR Points on Managing Difficult Rheumatoid Arthritis

Aug 19, 2021

Treatment of RA may be difficult, as it is estimated that up to 10% of patients meet the EULAR definition of difficult-to-treat rheumatoid arthritis (D2T RA). Now a EULAR task force has promulgated several points to consider (PtCs) in managing D2T RA.

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COVID Breakthrough Infections in Rheumatic Patients

Sep 08, 2021

Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with systemic autoimmune rheumatic diseases (SARDs) are not uncommon, and may be severe or fatal.

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Drug Choices After First TNF Inhibitor in RA

Aug 30, 2021

Tumor necrosis factor inhibitors (TNFi) are frequently used first line in rheumatoid arthritis (RA) patients; and a new analysis shows that repeat use of TNFi dominates over the use of non-TNFi biologics when the initial TNFi therapy has failed.

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RheumNow Podcast – JAK Inhibitor Warnings from the FDA

Sep 02, 2021

Dr Jack Cush reviews the news, journal articles and FDA warnings from the past week on RheumNow.com

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ICYMI: The Greatest Rheumatologist - Part I

Sep 06, 2021

Who is the greatest rheumatologist? What makes for a great rheum?

Is it clinical acumen, scientific achievement, educational prowess or years of unrivaled service or mentoring?

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Rare Risks Associated with BNT162b2 mRNA Covid-19 Vaccine

Aug 26, 2021

The current NEJM reports that the use of the Pfizer mRNA vaccine (BNT162b2) demonstrated a very low risk for certain serious adverse events, including the risk of myocarditis (1 to 5 events per 100,000 persons). 

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Predictors of Inflammatory Arthritis

Aug 31, 2021

Data from 4 parallel case-control studies within The Health Improvement Network looked at risk factors for developing psoriatic arthritis (PsA), psoriasis, rheumatoid arthritis (RA), and ankylosing spondylitis (AS) showed both shared and differentiating risk factors, but statin use was protective

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RheumNow Podcast – COVID Marching Amidst the Madness (8.27.2021)

Aug 26, 2021

Dr. Jack Cush reviews the news, journal reports and cautions regarding COVID-19

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Biologic Therapy of Psoriasis May Prevent Psoriatic Arthritis

Aug 24, 2021

Another retrospective cohort study has shown that biologic treatment of psoriasis may reduce the subsequent incidence of psoriatic arthritis (PsA).

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Not All Immunosuppression Alters Vaccine Immunogenicity

Sep 02, 2021

Chronic inflammatory disease (CID) patients are urged to receive the COVID-19 vaccines; but when a cohort of CID patients treated with immunosuppressive medications were given an mRNA-based SARS-CoV-2 vaccination, only those treated with glucocorticoids and B cell depleting therapies (BCDT) had l

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RheumNow Podcast – High Science and Future Treatments (9.10.2021)

Sep 10, 2021

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com

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Rheumatic Events With Checkpoint Inhibitors: Tumor Type Matters

MedPage Today
Aug 24, 2021

Among the factors that were associated with an increased risk for the development of rheumatic immune-related adverse events following cancer treatment with immune checkpoint inhibitors (ICIs) was the type of malignancy involved, a large case-control study found.

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HHS, FDA & CDC Joint Recommendation on COVID Booster

FDA
Aug 19, 2021

Today, public health and medical experts from the U.S. Department of Health and Human Services (HHS) released the following statement on the Administration’s plan for COVID-19 booster shots for the American people.

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High Drug Switching and Low Persistence in Rheumatoid Arthritis

Sep 13, 2021

Mease and colleagues have catalogued the current practices assessed in the CORRONA registry, noting that increased DMARD switching and decreased time on a given therapy by US physicians.

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RheumNow Podcast – Driving in Pain (8.20.2021)

Aug 20, 2021

Dr. Jack Cush reviews the news, journal articles and more from this past week on RheumNow.com.

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The Predictive Value of Morning Stiffness

Aug 25, 2021

A prospective study evaluated the value and associations with morning stiffness (MS) in patients with clinically suspect arthralgia (CSA), and found that the presence of MS increases the odds of inflammation (as detected by CRP and MRI synovitis).

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