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Lupus

Serious Infection Risk High in Patients With Lupus

MedPage Today
Sep 17, 2021

Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found.



In a multivariate analysis that adjusted for age, sex, region of residence, and education, the hazard ratio for serious

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RheumNow Podcast – High Science and Future Treatments (9.10.2021)

Sep 10, 2021

This week: high science that affect future treatments; breakthrough infections in our patients, and what's up with that; and soon your radiologist is going to be replaced by AI. This and more in our review of the news and journal articles from the past week.

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Risk Factors Associated with Systemic Sclerosis Hospitalization

Sep 09, 2021

A retrospective study of systemic sclerosis patients shows that acute hospitalization and mortality were not uncommon and were often linked to SSc-related lung disease.



Record review of 95 SSc patients from a single-centre cohort seen between 2010 and 2020 found that over half (53

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Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with SARDs are not uncommon, and may be severe or fatal. https://t.co/Ri5QipR7YY https://t.co/TaTFTKfAzm
Dr. John Cush @RheumNow( View Tweet )
Sep 09, 2021
Two cohorts from the Nurses’ Health Study (1984–2014 & 1991–2013) showed no association between diet & increased risk of incident #SLE; but that a high nut/legume diet may be associated with a reduced SLE risk https://t.co/mbBs7KZA6A

Dr. John Cush @RheumNow( View Tweet )

Sep 08, 2021

COVID Breakthrough Infections in Rheumatic Patients

Sep 08, 2021

Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with systemic autoimmune rheumatic diseases (SARDs) are not uncommon, and may be severe or fatal.



Researchers

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ICYMI: Using inpatient hospital records of 1.9 million SLE pts, the mortality of hospitalized #SLE changed little from 2006-2016;mortality dropped from 2.2% to 1.5% - with most of this decline between 2006-‘08 and no change since. Racial disparities seen. https://t.co/UUsJYFxQS4

Dr. John Cush @RheumNow( View Tweet )

Sep 05, 2021
Using inpatient hospital records of 1.9 million SLE pts, the mortality of hospitalized #SLE changed little from 2006-2016; mortality dropped from 2.2% to 1.5% - with most of this decline between 2006-2008 and no change since. Racial disparities seen. https://t.co/UUsJYFxQS4

Dr. John Cush @RheumNow( View Tweet )

Sep 02, 2021
Multi-center study of 215 pediatric SLE patients - 55%(118) w/ Hematologic findings: most common anemia (88), hemolytic anemia (4). Signif assoc w/ HEME dz: Renal Dz, low C3, APL Abs, anti-β2 GP1, Sm, LAC, high SLEDAI. Most Rx w/ steroids, IVIG or RTX https://t.co/nuD524kkD4 https://t.co/6a14bQ6SQ6
Dr. John Cush @RheumNow( View Tweet )
Sep 01, 2021
Watch: Drs. Jack Cush, Kathryn Dao ( @KDAO2011) , Janet Pope ( @Janetbirdope) Eric Dein ( @ericdeinmd) and Yuz Yusof discuss a number of lupus presentations presented at the virtual EULAR 2021 meeting. #RheumNow https://t.co/yUEXTOatpR

Dr. John Cush @RheumNow( View Tweet )

Aug 31, 2021
NIAID will study COVID‐19 Booster Vaccine in Autoimmune Disease Non‐Responders (including MS, RA, SLE, Scleroderma,pemphigus); 20 sites, 600 pts (taking MTX, MMF or RTX) w/ poor resp to mRNA vax & recv 3rd booster vax. https://t.co/YwCvGnX21F https://t.co/th2WoRv1ng

Dr. John Cush @RheumNow( View Tweet )

Aug 31, 2021
Swedish study of 287 SLE pts shows rare risk of autoimmune liver disease. While 14% had persistent LFTs, only 2.8% dx w/ autoimmune hepatitis. 1.4-2.1% met criteria for primary biliary cholangitis. Both AIH & PBC AIH are overrepresented in SLE https://t.co/oc5SLJtycf

Dr. John Cush @RheumNow( View Tweet )

Aug 27, 2021
Brazilian national study of 319 SLE & 251,800 nonSLE pts hospitalized with COVID-19 showed that SLE increases risk of death (RR 1.74) & poor outcomeS (RR 1.39). Having lupus doubled (RR 2.2) the risk of risk of death. https://t.co/8VJjdOEuzS

Dr. John Cush @RheumNow( View Tweet )

Aug 27, 2021

RheumNow Podcast – COVID Marching Amidst the Madness (8.27.2021)

Aug 26, 2021

We have a lot of news, information and approvals to review and discuss, though I need to begin with what's weighing heavily on my mind. After, we'll dive into what we learned this week.

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Among pregnant women, receipt of the BNT162b2 vaccine was associated with a 78% lower risk of incident SARS-CoV-2 infection. Cohort study tincluded 15 060 pregnant women in Israel. No adverse pregnancy outcome difference in Vax Pts https://t.co/jXUjaKIfUV

Dr. John Cush @RheumNow( View Tweet )

Aug 25, 2021
Rheums--have a question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/wzNmOzH4VE https://t.co/QJn6Uo3lbM
Dr. John Cush @RheumNow( View Tweet )
Aug 24, 2021
Comprehensive, full read overview of (European EADV) S2k guideline: Diagnosis and management of cutaneous lupus erythematosus – Part 1 (classification, Dx, activity) & Part 2 (Treatment) https://t.co/puBCr8VO1I https://t.co/rZKDEsvDzr

Dr. John Cush @RheumNow( View Tweet )

Aug 23, 2021
The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed. https://t.co/UpQjFgKTpE https://t.co/3dQ2jacwJD
Dr. John Cush @RheumNow( View Tweet )
Aug 23, 2021
ICYMI: Belimumab in Pregnancy? a study of 13 pregnancies in 13 pts, mean age 38 yrs.. There were 11 live births, 1 case omphalitis (recovered w Abx) . No fetal anomalies found. 6 pts (46%) w/ Hx of recurrent pregnancy loss, four had live births on BEL https://t.co/FJJhepa25M

Dr. John Cush @RheumNow( View Tweet )

Aug 22, 2021
Important read re:G6PD testing prior to HCQ Rare & not assoc w/hemolytic anemia in this cohort, but only 11 pts with G6PDH deficiency I'm v. skeptical of G6PD screening; cost (no HCQ in SLE) could easily be worse than benefit (avoiding hemolytic anemia) Do you routinely test? https://t.co/HI2PuF1Xq9
Mike Putman @EBRheum( View Tweet )
Aug 18, 2021
Check for APAs and LAC in SLE pts with hemolytic anemia https://t.co/hlGfnq89Pz
Aug 18, 2021
Popular post-- AstraZeneca announced that anifrolumab (Saphnelo or anifrolumab-fnia) was approved by the the FDA for that treatment of adult patients with moderate to severe systemic lupus erythematosus (SLE) who are receiving standard therapy. https://t.co/22HVA32IAh https://t.co/CGkBW80un4
Dr. John Cush @RheumNow( View Tweet )
Aug 16, 2021

RheumNow Podcast – Booster Shots for COVID (8.13.2021)

Aug 13, 2021

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.




  1. In a head to head trial Upadacitinib was superior to Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis. 24wk DBRCT, 924 pts given either UPA 30/d vsDUP 300 EOW. ESI75 response@

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Interesting case report of difficult periorbital Discoid lupus erythematosus (DLE) treated with topical tofacitinib, 2%, ointment, a topical Janus kinase (JAK) 1/3 inhibitor. https://t.co/NZxUFW9ilN

Dr. John Cush @RheumNow( View Tweet )

Aug 12, 2021
Drs. Jack Cush, Kathryn Dao, Janet Pope, Eric Dein and Yuz Yusof discuss a number of lupus presentations as well as abstracts presented at the virtual EULAR 2021 meeting. Lupus nephritis and treat-to-remission presentations were discussed by the panel. https://t.co/dfRdeveeLp

Dr. John Cush @RheumNow( View Tweet )

Aug 11, 2021
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