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OP/Bone

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Methotrexate Monitoring (5.13.2022)

May 13, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.




  1. Risk factors for readmission among 132,400 #SLE hospitalizatiions included

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Wiki Guidelines Approach to Pyogenic Osteomyelitis

May 12, 2022

A crowd sourced, WikiGuidelines approach to clinical treatment guideline development for pyogenic osteomyelitis yielded 7 important clinical questions, 2 clear treatment recommendations and 5 topic reviews to inform future treatment or investigations.



Some clinical scenarios may be

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Liver,hepatic,red

Arthritis Predicts Hepatic Fibrosis in Hemochromatosis

Apr 25, 2022

Mayo Clinic Proceedings reports the results of a retrospective, cross-sectional of patients with HFE hemochromatosis showing that advanced hepatic fibrosis is primarily seen in those with arthritis due to HFE hemochromatosis. 



A total of 112 patients with a liver biopsy confirmed

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What I learned... always get an ALP and phosphorus level in people with chronic bony pain. https://t.co/nE0xYwODmC

TheDaoIndex @KDAO2011( View Tweet )

Apr 09, 2022
OP is worse w/ Inflammation; would biologics reduce OP and Fx risk? Swedish study of 24,678 RA pts, 4265 on biologics - Over time, the OP Fx rates were 12.1 vs 13.0 per 1000PY with and without biologics (HR 0.97; 0.78-1.20); Thus no Fx benefit https://t.co/d2zGd0WWoa https://t.co/Z9HVMUQd5U
Dr. John Cush @RheumNow( View Tweet )
Mar 04, 2022
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ACR Guidelines for the Treatment of Systemic Juvenile Idiopathic Arthritis

Mar 03, 2022

The ACR has updated its clinical guidelines for the management of juvenile idiopathic arthritis (JIA), with this update focusing on oligoarthritis, TMJ arthritis, and systemic JIA (with and without macrophage activation syndrome); only the latter, systemic JIA recommendations are reported

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Positive Results from the DOA (Duloxetine in OsteoArthritis) Study

Feb 21, 2022

A pragmatic, open-label trial of osteoarthritis (OA) patients demonstrated that adding duloxetine treatment seems to be beneficial for end-stage knee OA patients with neuropathic-like symptoms (at risk of central sensitization).



While duloxetine is approved for the treatment of

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ICYMI: Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/P4SzIrWzYJ https://t.co/wnf3vnG4xc
Dr. John Cush @RheumNow( View Tweet )
Feb 20, 2022
DIP,OA

Why Would Hand OA Be Less Severe in Black People?

MedPage Today
Feb 08, 2022

Osteoarthritis (OA) of the hand was less severe according to objective and pain-related markers in Black patients versus those of other racial/ethnic groups after adjustment for known risk factors, researchers found.



The finding was a major surprise and somewhat mysterious, insofar as

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Hip fractures in elderly occur at >250 000/YR in US w/ a 1-yr mortality rate, 12%-37%. During COVID-19, surgery volumes among older individuals were lower than 2 years previously starting spring 2020 until vaccine was widely available https://t.co/80YQq1gyhA

Dr. John Cush @RheumNow( View Tweet )

Feb 08, 2022
The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH).https://t.co/6ztalAZrII https://t.co/ONXaGJI15v
Dr. John Cush @RheumNow( View Tweet )
Feb 07, 2022
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X-Linked Hypophophatemia - Survey Results

Feb 04, 2022

The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH). Although rare, XLH can be a diagnostic consideration in patients with recurrent fractures, rickets, osteomalacia and

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ICYMI: Annals of Internal Medicine describes a propensity matched comparison study of risedronate and alendronate, showing that, compared to alendronate, risedronate drug holidays were associated with a small increase in risk for hip fractures. https://t.co/6qnMUzqV3E https://t.co/iIrahEuB09
Dr. John Cush @RheumNow( View Tweet )
Jan 23, 2022
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Fracture Risk with Osteoporosis Drug Holidays

Jan 17, 2022

While bisphosphonate drug holidays are recommended, there are few comparative studies. Annals of Internal Medicine describes a propensity matched comparison study of risedronate and alendronate, showing that, compared to alendronate, risedronate drug holidays were associated with a small

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Best of 2021: Jack of All Subspecialties

Dec 31, 2021

It's great to be a rheumatologist, but boy, it's getting harder and harder. You have to be a jack of all trades. You have to be good at cardiovascular disease, osteoporosis, vaccination, inflammatory bowel disease - it just never ends. This and more, as Dr. Cush summarizes more than a dozen

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Best of 2021: Tofacitinib Safety Concerns

Dec 29, 2021

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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Best of 2021: EULAR Guidelines on Intraarticular Therapy

Dec 20, 2021

EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.



The

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NYC Hosp for Special Surgery is the 1st to use a "smart" knee arthroplasty - TKR with a smart sensor capable of monitoring steps, speed, range of motion & other knee functions fed back to the orthopedist = called Persona IQ, FDA authorized https://t.co/QR49JC7oCz

Dr. John Cush @RheumNow( View Tweet )

Dec 13, 2021
Geriatric Rheumatology:Improving care of aging patients Dr.Kathryn Dao ( @KDAO2011) moderates a panel w/ Drs.Una Makris, Katherine Wysham, Sebastian Sattui + Devyani Misra, as they discuss aspects of improving care of/outcomes for aging patients. #ACR21 https://t.co/lF3yUZBEkd https://t.co/hYufA8ptqj
Dr. John Cush @RheumNow( View Tweet )
Nov 19, 2021
Osteoporosis in PsA: Dr. Rachel Tate ( @uptoTate) discusses Abstract #1325, presented at the #ACR21 annual meeting.https://t.co/xnRkPnHeTr https://t.co/nE3ehhCB4j
Dr. John Cush @RheumNow( View Tweet )
Nov 18, 2021
Dr. Lane on Ca/Vitamin D in Osteoporosis ⭐️🎯serum vitamin D 25OH ~38 ⭐️Studies since 2008 Auckland Calcium trial DO NOT support incr CV risk with Ca supplementation ⭐️Ca calculator: https://t.co/PLPMfZdIwb⭐️No sig change in fracture risk with supp #ACR21 #ACRAmbassador https://t.co/KUa52vf4gT
Veena Katikineni @VeenaRheumMD( View Tweet )
Nov 09, 2021
Dr Adachi presents ⬆️BMD gain with denosumab than risedronate in RA. Non-significant reduction in fractures (very small numbers) Interesting, but need to see fracture benefit in larger study to justify dmab as first line Abstr#0445 #ACR21 @RheumNow https://t.co/GgaS9JZGzb
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
A meta-analysis of 5 cohort studies showed that PsA is significantly associated with vertebral fractures pooled OR 2.09 (95% CI, 1.11 – 3.96; I2 70%). The review was not suggestive of publication bias @RheumNow #ACR21 Abst#1304 https://t.co/rjC776FXUA https://t.co/QvMWxN6ZZ7
Dr. Antoni Chan @synovialjoints( View Tweet )
Nov 08, 2021
Meta-analysis shows increased risk of vertebral fracture in PsA, OR 2.09. Abstr#1304 #ACR21 @RheumNow https://t.co/kTrR7I3HA0
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
#ACR21 A#0563 - Is FRAX score applicable for RA? 10 yr Olmsted County epi study: Yes ▶️ 76 osteoporotic fxs in RA pts, FRAX predicted 67 fx (SIR 1.13, not signif) ▶️ 21 observed hip fx, FRAX predicted 23.3 (SIR 0.9) ⭐️ No differences by ages/sexhttps://t.co/vWy7EmseZp @Rheumnow https://t.co/8BlzgQYqaV
Nov 07, 2021
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