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Bone/OP&OA

Fibromyalgia Therapies Show Limited Evidence of Pain and QOL Reduction

Oct 27, 2020

JAMA Internal Medicine has published a review showing that most currently approved therapies for fibromyalgia (FM) do not have high-quality evidence to support their use; with some reducing pain or improving quality of life (QOL) in the short term, but overall effect size is not impressive.

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Listent to QD Clinics - A Podcast Weekly Compilation - Lessons from the clinic. Dr.

Dr. John Cush RheumNow ( View Tweet)

Oct 25, 2020
Korea National Health databased looked at Fracture rates in RA patients taking TNFis, abatacept, or tocilizumab betw 2002 to 2016. They found no difference in Fx risk related to the biologic taken. https://t.co/W2dWWseXTc

Dr. John Cush RheumNow ( View Tweet)

Oct 22, 2020
Not sure why this study was done...BUT...

Dr. John Cush RheumNow ( View Tweet)

Oct 19, 2020
Another case of COVID-19 Arthritis; 58 yoF w/ non-severe COVID-19, (by qRT-PCR ) had arthralgia, fever, cough, nausea, diarrhoea, dysgeusia, and devloped ankle arthritis CRP 7·36 mg/L, lymphopenia (1·29) persistent arthritis (by US) and +Sars-CoV-2 in SF.

Dr. John Cush RheumNow ( View Tweet)

Oct 09, 2020

RheumNow Podcast – Bad Disease & Bad Outcomes (10.9.20)

Oct 08, 2020

Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com.

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Lockdown worsening; UK survey 678 patients musculoskeletal diseases pts in late April 2020 shows 53% worsening of Sx; 1/3 had clinic/hosp access probs problems & most (88%) had no probs w/ getting meds; but 44% needed others to help them get meds.

Dr. John Cush RheumNow ( View Tweet)

Oct 07, 2020

IL-1 Inhibition Alters Arthroplasty Rates

Oct 07, 2020

A subanalysis of the CANTOS trial suggests that inhibition of interleukin-1β (IL-1β) can reduce rates of incident hip or knee replacement (THR/TKR) surgeries.

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Fractures from Delays in Denosumab Reinfusions

Oct 07, 2020

Denosumab is effective in osteoporosis when used on schedue, but research suggests that discontinuation leads to rapid reversal of effect; a new observational study has shown that delays in denosumab administration of more than 16 weeks results in an increased vertebral fracture risk,

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388 RA pts Rx w/ either b/tsDMARD (Group I) or csDMARD (Group II) . After 3 years, BMD stable at the femoral neck, hip and lumbar (L1–4) (P =0.09, 0.15, 0.87) in Group I, but .

Dr. John Cush RheumNow ( View Tweet)

Sep 30, 2020
Small study compared denosumab (20 pts) and teriparatide (21) in glucocorticoid-induced osteoporosis (GIO) Pts not responding to bisphosphonates.

Dr. John Cush RheumNow ( View Tweet)

Sep 29, 2020
Study of early axSpA from the DESIR cohort looked at MRIs of the SI joint/spine @baseline, 2 & 5 yrs; showed that bone marrow edema pn MRI‐SIJ and ‐spine at baseline predicted of ‐year damage pm MRI‐SIJ [OR=4.2] and MRI‐spine [OR=10.7] https://t.co/3PAJ5Zt4Pp

Dr. John Cush RheumNow ( View Tweet)

Sep 28, 2020

RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

Sep 24, 2020

Dr. Jack Cush reviews the news and Journal articles from the past week on RheumNow.com.

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EULAR Updated 2019 Recommendations for Psoriatic Arthritis Management

Sep 24, 2020

In June 2020, we failed to report on the ARD publication updating the 2019 update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA) - these are presented below.



This guideline committee included 28

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Pain in Knee Osteoarthritis comes from what?

Dr. John Cush RheumNow ( View Tweet)

Sep 22, 2020
A machine-learning algorithm was developed using MRI data from the Osteoarthritis Initiative capable of predicting osteoarthritic progressors from baseline cartilage texture maps ; Had a test accuracy of 78% in detecting OA progression 3 y prior to Sxs https://t.co

Dr. John Cush RheumNow ( View Tweet)

Sep 22, 2020

RheumNow Podcast – Lupus Delights (9.18.20)

Sep 18, 2020

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

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Has the Risk of Hip Fracture Changed over Time?

Sep 16, 2020

Data from the Framingham Heart Study has shown that hip fracture incidence has decreased over time, probably resulting from improved lifestyle changes (less smoking and heavy drinking). 



The incidence of hip fracture has been shown to be decreasing in the US, presumeably attributeable

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NSAIDs Shows No Advantage over CBT in Knee Osteoarthritis

Sep 16, 2020

JAMA Internal Medicine reports on a controlled clinical trial of knee osteoarthritis patients wherein meloxicam responses were not significantly or clinically superior to placebo or CBT (after placebo).



Because of the uncertain benefits and safety of long-term NSAIDs,

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Capsaicin Injection Improves Knee OA Pain

Sep 15, 2020

Highly purified synthetic trans-capsaicin (CNTX‐4975) injected directly into the joint reduced pain in chronic knee osteoarthritis (OA), data from the open-label phase III VICTORY-3 trial showed.



People with bilateral knee OA pain who received the investigational treatment had less

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4033 Dual-energy CT lesions from 27 pts (23 gout; 4 nonGout) shows definite MSU deposits in MTP1 & patella tendons (high density/volume, low DECT ratio) & non-gout lesions seen in larger jts (knee, midtarsal, talocrural) & tendons (Achilles, quadriceps)

Dr. John Cush RheumNow ( View Tweet)

Sep 14, 2020

RheumNow Podcast – To Celiac Test or Not? (9.4.20)

Sep 04, 2020

Dr Jack Cush reviews the news, journal articles and takes a few Back Talk questions this week:

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Metanalysis of 11 RCTs (1353 patients) shows that saline injections are as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain https://t.co/z7jhOSUwQU

Dr. John Cush RheumNow ( View Tweet)

Sep 03, 2020
Finish DBRPCT study of 146 adults w/ arthroscopic partial meniscectomy (APM) for med meniscal tear shows no clinical benefit after 5 years; but those with APM had slight, nonsignificant increase in Xray knee osteoarthritis (vs sham control) https://t.co/SFRvBH7gNh

Dr. John Cush RheumNow ( View Tweet)

Sep 03, 2020
Falls are common after total hip arthroplasty - Cohort of 108 individuals (age of 72.4 yrs) w/ total hip arthroplasty followed 12 mos. 23% had a FALL; half (56%) w/in 6–12 mos of surgery. https://t.co/UXeB3cMuMO

Dr. John Cush RheumNow ( View Tweet)

Sep 01, 2020
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