2022 Rheumatology Year in Review (1-6-2023)
Jan 06, 2023
Dr. Jack Cush reviews the best of 2022 in Rheumatology - highlights on new drug indications, breakthrough lupus therapies, new biosimilars and the multivitamin letdown.
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CDC: Nursing home residents not up to date w/COVID-19 vaccines have 30%–50% higher risk for COVID infx vs those up to date. Betw 2022-23 Those vax had COVID rate of 7.2-15.6/1000pts vs 9.5-18.8/1000 pt in those unvaccinated. https://t.co/Eem2H5AMoN https://t.co/o2ZyPVswZp
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Jan 27, 2023
UK Database 1,955 breakthrough COVID-19 infxs in 54,576 #gout pts compared to 52,468 w/o gout saw more in gout (adj HR 1.24), also w/ more #COVID hospitalizations (adj HR 1.30) & death (1.36), more so in women. Same for unvaccinated https://t.co/596KvupZxi https://t.co/BJJguQBdin
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Jan 10, 2023
Autoimmune Dz may be assoc w/ new-onset Atrial Fibrillation, esp in women. Population-based UK Biobank found significant increases for AFib in Rheumatic fever w/o CVD (HR 1.47), Crohn’ (1.23), UC(1.17), RA (1.39), PAN (1.82), SLE (1.82), PSS (2.32) https://t.co/rpIiztUfg9 https://t.co/FWmLiZ6x1S
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Jan 10, 2023
Should Kids w/ MIS-C get the COVID vaccine? Yes - study of 385 pt > 5 yrs w/ Hx of multisystem inflammatory syndrome showed no serious adverse events after COVID-19 vaccination. The safety profile of COVID-19 vax is same as gen population https://t.co/dr2QBQsMhE? https://t.co/WbsUuYEsez
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Jan 06, 2023
On Wednesday 12/21 the FDA approved tocilizumab (Actemra; 8 mg/kg, 60-min IV infusion ) for hospitalized COVID-19 on steroids, supplemental O2 & req ventilation, or ECMO; 1st MAb approved for COVID-19; Prev EUA issued in June 2021 https://t.co/BswLu4ZY5O https://t.co/7gpPkeoPZ4
Dec 22, 2022
COVID-19 Vaccine Responses in Rheumatic Disease Patients
Nature Reviews Rheumatology features a review of three notable papers that address the impact of SARS-CoV-2 vaccination on people with inflammatory rheumatic disease. https://t.co/R9UM3amPRR. https://t.co/WmHyVKdsxw
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Dec 19, 2022
COVID-19 Vaccine Responses in Rheumatic Disease Patients
Dec 16, 2022
Nature Reviews Rheumatology features a review of three notable papers that address the impact of SARS-CoV-2 vaccination on people with inflammatory rheumatic disease.
Studies on the efficacy and safety of the COVID-19 vaccines, have shown rapid and strong development of immunity in
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During 2021–22 FLU season, 6% of hosp pedi-influenza pts had SARS-CoV-2 coinfection; these required more respiratory support. Risk of influenza death augmented by not recv vaccination (flu or covid), no antiviral Rx, comorbidities & coinfx w/COVID https://t.co/bfjeClHflW https://t.co/YTOEnNSQQN
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Dec 15, 2022
Recent CDC/MMWR report shows Paxlovid x 5days (including those w/ prior COVID or vaccination), had a 51% lower hospitalization rate within 30 days after diagnosis than those not prescribed Paxlovid. Use it irrespective of vaccination status https://t.co/CBc1VBSDFR https://t.co/EC8QGaFrb3
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Dec 02, 2022
TIME Mag - "Why Masks Still Matter". 1) COVID is still out there; 2) Influenza on the rise. Authors write "With limited yet mixed data, we would be wise to ...err on the side of masking in high risk, indoor crowded public settings..." https://t.co/l8jiTwAdZz https://t.co/0QUKJDOhjs
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Nov 28, 2022
Does Evusheld shield people living with rheumatic diseases?
Dr. Yuz Yusof ( @Yuz6Yusof) discusses three key abstracts from #ACR22 on Evusheld findings.https://t.co/wYl6Wpd5Fs https://t.co/7T7u4czNOX
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Nov 27, 2022
COVID Highlights
Dr. Leonard Calabrese and Dr. Cassandra Calabrese share highlights on COVID data being presented at #ACR22 https://t.co/DEUykGt8pT https://t.co/sz8GRRGrPH
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Nov 23, 2022
Impact of COVID 19 on Pregnancies in Women with RMD
Dr. Cassy Sims ( @DrCassySims) discusses abstract 0950 at #ACR22. https://t.co/qbFRV5P3eP https://t.co/cmS4n15L5e
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Nov 23, 2022
Vaccination +/- prior Covid-19, and with either mRNA or vectored DNA vaccines were not associated with AIRD flares. Negative association 21-days after 1st Covid-19 vaccination and no association after 2nd or 3rd doses. Nakafero G Abs#2194 https://t.co/vA8cMNQGkr #ACR22 @RheumNow https://t.co/SZnXejnmYt
Nov 14, 2022
Problem w antibodies to prevent #COVID19 infection in rheumatic Pts is that they are not as good in variants that are more prominent ex Omicron strains. But should we use in high risk Pts ex long rituximab users? I do in this group. @RheumNow #ACR22 https://t.co/A8soYbg9ZD
Nov 14, 2022
L08 #ACR22 TIX/CIL (Evusheld) in Rheum Pts
157 pts, f/u 154 days
24 breakthrough COVID ifns (15%)
2 pts required hospitalization, rest had mild-mod symptoms
No SAEs (CVD)
@RheumNow
Nov 14, 2022
In a prospective cohort where MTX was withheld for 1 week post COVID vaccine, antibodies higher than other DMARDs which were continued (mostly RTX/MMF).
Good to see more direct data rather than having to extrapolate from flu.
@RheumNow ABST0913 #ACR22https://t.co/YphKywNJfA
Nov 14, 2022
Even young SLE patients are still at high risk of severe COVID:
- in general pop, age is key factor
- in SLE, risk is high across age groups (maybe due to both meds & disease)
- vaccination makes a big diff but SLE pts still at high risk
ABST1591 @CCalabreseDO #ACR22 @RheumNow https://t.co/ra1F79ITn3
Nov 14, 2022
Vaccine Efficacy in Patients with Seronegative Spondyloarthritis
Nov 14, 2022
Vaccine efficacy remains an important and highly discussed topic at this year’s annual meeting given the ongoing COVID-19 global health crisis, current influenza season, and recently published 2022 ACR guidelines for vaccinations in patients with rheumatic and musculoskeletal diseases.
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#ACR22 Abstr#1756 More data on safety of #COVID vaccine to cite when counselling patients with inflammatory arthritis (IA). Data from COVAX registry (over 7000 pts) showed rates of serious adverse event was low 0.3% vs 2.5% in those with non-IA RMD group
@RheumNow https://t.co/iucDK1GpU4
Nov 14, 2022
The pandemic has brought many challenges to our community. One of them is the lingering effects of COVID-19.
#PASC #COVID #ACR22 #RheumTwitter https://t.co/AlwUHX2cao
Nov 14, 2022
All monster stories end with an unexpected award: A new order
@cuttingforstone at #ACR22 tells the monster story of #covid
“How will history review our story?”
The science will get an A+, but we failed to learn the lessons of history
All was predictable through history
@RheumNow
Nov 13, 2022
Everyday heroes during #COVID19 Keynote @ACRheum Health care workers who were minorities disproportionately died in the early days of the pandemic. Can’t be all SES as risk but maybe ‘status’ as first line workers. Remember them #ACRBest #ACR22 @RheumNow @AbrahamVerghese 🙏🏻 https://t.co/AjkV5wDVEu
Nov 13, 2022
Please read my short review on early experience/data pertaining to the use of #Evusheld in patients with rheumatic and musculoskeletal diseases presented at #ACR22 @RheumNow https://t.co/JA7WsWqMmz https://t.co/MRA0mQFIu8
Nov 13, 2022
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Best of 2022: Freeze Tag
Dec 28, 2022
