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ACR 2019 - Report from Day 3 (Tuesday)

Here's my summary of key studies presented Tuesday. 

Tofacitinib in Polyarticular JIA

Rheumatic immune-related adverse events: not just another irAE

Rheumatic immune-related adverse events can start at almost any time after the commencement after immune checkpoint inhibitor immunotherapy for cancer, and are liable to persist long after the immunotherapy has ceased, according to data presented at ACR 2019 in Atlanta, Georgia.

Herpes Zoster Vaccine Update

Shingrix (GSK), the herpes zoster subunit vaccine (a two-shot series), was approved by the FDA in Fall 2018 and is currently approved for use in adults 50 years and older.

Pegradicase+immTOR SEL-212 Shows Promising Results in Active Gout

Therapies targeting sUA accumulation or improving its excretion are widely used for treatment of symptoms and prevention of progression of gout for decades.

Tweets

Janet Pope Janetbirdope

8 months ago

1/3 of pts using apremilast with PsA/SpA from Corrona data base are using it in combination with bDMARDs. Not sure how they get reimbursement #ACR #ACR19 #psoriaticarthritis @RheumNow abstract 1481

Kanika Monga, MD DrKanikaMonga

8 months ago

@RheumNow 2020 Gout Clinical Practice Guideline ‼️ For allopurinol and febuxostat, strongly recommend starting at low dose with subsequent dose titration to target over starting at higher dose ( ≤ 100 mg/d for allopurinol, ≤ 40 mg/d for febuxostat) #ACR19 @RheumNow

Janet Pope Janetbirdope

8 months ago

Infections In out patients are increased as measured by antimicromial scripts with RA and TNFi use comparing popn controls and pre and post RA TNFi use in pan Iceland registry #ACR19 #ACR @RheumNow abstr 2873. Higher than controls pre &even more after TNFi https://t.co/SlkIPP9WsJ

Cassandra Calabrese CCalabreseDO

8 months ago

Continue or stop biologics for RA if pregnant? Abstr# 2292 and 2279 show increase in flares, GC use, if biologics stopped at time of positive pregnancy test @RheumNow #ACR19

Janet Pope Janetbirdope

8 months ago

Tofa is not different from bDMARDs in Corrona for cancer and deaths. reassuring and adds to growing safety data #ACR #ACR19 @RheumNow abstr 2874 https://t.co/pLVAkQ7UR6

Cassandra Calabrese CCalabreseDO

8 months ago

RA patients failing either UPA or adalimumab may benefit from switching to the other therapy abstr#2907 #ACR19 @RheumNow

Kanika Monga, MD DrKanikaMonga

8 months ago

What contributes to serious infections in RA? Higher inflammation and GC use, not bDMARD or tofacitinib use increased infectious risk Bella Mehta et al. RMD Open 2019 #ACR19 @RheumNow

Kanika Monga, MD DrKanikaMonga

8 months ago

- Risk of bDMARD withdrawal higher for TNFi monotherapy compared w/ cs/bDMARD combination - If monotherapy necessary, etanercept should be preferred over infliximab and adalimumab Silvagni E et al. BMJ Open 2018 #ACR19 @RheumNow

Janet Pope Janetbirdope

8 months ago

Prednisone is associated with organ damage in SLE. Chicken or egg argument? Bad lupus gets more steroids and more damage AND steroids independently increase CV events and other damage ex OP and cataracts #ACR19 @RheumNow abstr 2562 #SLE https://t.co/onEII3OKhS

Mike Putman EBRheum

8 months ago

Great talk by Dr. Manzi for Year in Review! See my recent podcast about SPIRIT-H2H. It shows that IXE > ADA for skin but NOT for joints. @RheumNow #ACR19 https://t.co/FzY8O7KX1A

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