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RNL 2022: Spondyloarthritis Spectrum

May 18, 2022

This RheumNow Live 2022 session features highlights from lectures on Spondyloarthritis.

- Microbiome in Spondyloathritis - Jose Scher, MD

- Axial Psoriatic Arthritis - Philip Mease, MD

- Juvenile Spondyloathritis - Pamela Weiss, MD

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Polygenic Risk Scores to Identfy Severe Knee and Hip Osteoarthritis

May 09, 2022

Prevention of knee and hip osteoarthritis would obviate considerable disability and future surgery.  We may be one step closer according to a prospective European GWAS study showing polygenic risk scores (PRSs) significantly associated with higher risks for knee and hip OA joint replacement

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Diagnostic Delays in Spondyloarthritis Still Prolonged

May 09, 2022

Previously quoted average  delay in diagnosing axial spondyloarthritis (axSpA) may be improving as a recent UK study shows the mean average time to diagnosis in two different NHS trusts was between five and six years. 

The diagnostic delay in axSpA has been attributed to a slower

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Neural networks of high-res quantitative CT (HR-pQCT) scans allowed for 3D imaging of MCP2 to differentiate normals from #RA & #PsA. 932 of 617 ppts correct AuROC for HC 82%, RA 75%, PsA 68%. UA pts read as 86% RA,11% PsA, & 3% HC
Dr. John Cush @RheumNow( View Tweet )
May 04, 2022

Prolonged TNF Inhibitor Use Delays Sacroiliac Progression

Apr 28, 2022

While tumour necrosis factor inhibitors (TNFi) have been shown to alter/retard X-ray outcomes in peripheral inflammatory arthritis, the inhibitor effects of TNFi on axial skeletal progression in spondylitis has been difficult to prove, owing to difficulties in study design, identifying best

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Now Available: TNR - Psoriatic Arthritis Journal Club

Apr 15, 2022

A recording of this week’s Tuesday Night Rheumatology is now available. This outstanding webinar featured a robust discussion of the EXCEED study and Discover-2 trial, with Drs. Philip Mease, Peter Nash, Jack Cush and Rachel Tate.

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Differences between Palpated & Ultrasound Joint exams in 155 #PSA patients. 5616 joints - found 18.5% tender, 9.8% swollen, 20.4% w/ US GS ≥ 2 and 5.2% had US PD ≥ 1. Joints that were both tender and swollen more likely to have GS ≥ (44%)
Dr. John Cush @RheumNow( View Tweet )
Apr 07, 2022
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RheumNow Live is Coming to Town (3.11.2022)

Mar 11, 2022

Dr. Jack Cush reviews the news and journal articles from the past week on

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Diagnostic Delay in Axial Spondyloarthritis (2.25.2022)

Feb 25, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on This week, rheumatologic problems incited by respiratory infections, air pollution and how you live, now where you live.

  1. Diagnostic delay in axial spondyloarthritis? Systematic review

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ICYMI: Dr Steen's recipe to dealing with digital ulcers.#RWCS2022 @RWCSmtg
Dr. John Cush @RheumNow( View Tweet )
Feb 20, 2022
ICYMI: Retrospective study of 98 patients with X-linked agammaglobulinemia (XLA) shows arthritis seen in 46% - more oligo- than polyarthritis, affecting . Knee, hip, and ankle. IVIG response rates around 70%; many w/ arthritis had missense mutation
Dr. John Cush @RheumNow( View Tweet )
Feb 20, 2022
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Hand OA and Heroes in Rheumatology (2.11.2022)

Feb 11, 2022

Interesting reports this week about dementia, who gets hand OA and a great list of women Heroes and Pillars of Rheumatology. Tune in as Dr. Jack Cush reviews the news and journal articles from this past week in

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Analysis of nearly 1000 undifferentiated-arthritis(UA) pts show that MRI use is most effective when applied to those who are seronegative or who have oligoathritis.

Dr. John Cush @RheumNow( View Tweet )

Feb 10, 2022

Why Would Hand OA Be Less Severe in Black People?

MedPage Today
Feb 08, 2022

Osteoarthritis (OA) of the hand was less severe according to objective and pain-related markers in Black patients versus those of other racial/ethnic groups after adjustment for known risk factors, researchers found.

The finding was a major surprise and somewhat mysterious, insofar as

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ICYMI: Radiographic progression in AxSpA studied in 101 Spanish Pts - pts w/ sustained low ASDAS had less XRay progression than those with active Dz (2.33 vs 1.76, p=0.027). Long term TNFi use didnt influence progression until the 3rd Yr

Dr. John Cush @RheumNow( View Tweet )

Feb 07, 2022
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An Ounce of Prevention (2.4.2022)

Feb 03, 2022

Dr. Jack Cush reviews the news and journal reports from this past week on  He discusses the GI side effects of IL-17 inhibitors, downstream revenues from rheumatology care and dietary prevention of gout. 

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ANCA, vasculitis, test

ACR/EULAR 2022 Classification Criteria for Microscopic Polyangiitis

Feb 02, 2022

The 2022 ACR/EULAR  classification criteria for microscopic polyangiitis (MPA) have been developed, validated and are now ready for use in clinical research.

An international cohort of patients with vasculitis or comparator diseases were recruited to first develop criteria and then

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GWAS study in RA used to develop polygenic risk score (PRS) for Xray progression (training set = 500 and validated testing set= 740). Risk factors for severe XRAY progr = PRS (P=0.00019), female (P=0.0033), ACPA (P=0.0023), BMI (P=0.031)

Dr. John Cush @RheumNow( View Tweet )

Jan 21, 2022

Referral Rules for At-Risk Inflammatory Arthritis

Jan 19, 2022

A prospective primary care study of patients at-risk for inflammatory arthritis (IA) showed that progression to IA was most likely in those with high anti-CCP antibody titers levels and involvement of the hands/feet/ IA. Interestingly, progression to IA was also seen in those who were

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Fracture Risk with Osteoporosis Drug Holidays

Jan 17, 2022

While bisphosphonate drug holidays are recommended, there are few comparative studies. Annals of Internal Medicine describes a propensity matched comparison study of risedronate and alendronate, showing that, compared to alendronate, risedronate drug holidays were associated with a small

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Autoantibody Associations in Systemic Sclerosis

Jan 04, 2022

Analysis of two large cohorts of systemic sclerosis (SSc) patients shows a signfiicant minority of patients to have autoantibodies typical of rheumatoid erosive arthrits, but their presence in SSc patients was associated with unique manifestations of SSc. 

Overall 448 SSC patiens were

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Feet, foot

Pre-clinical RA: starting off the wrong foot

Patients with clinically suspect arthralgia can represent a challenge for clinicians, in a sense that there are not yet reliable markers to predict evolution to clinical RA nor enough evidence to support routine prescription of conventional synthetic DMARDS or biologic treatments in this setting

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TNF inhibitors and radiographic progression in axSpA

A remaining challenge for clinicians is the ability to delay, if not completely stop, structural progression in patients with axSpA, whether they are diagnosed with radiographic (r-axSpa) or non-radiographic (nr-axSpA) disease.

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heel enthesitis spur calcaneal

Predicting RA, and Treatment of Subclinical Arthritis

Identifying patients that will develop RA in situations of seropositivity without overt clinical arthritis or identifying patients with undifferentiated oligo/polyarthritis that will develop RA remains a challenge in the field of rheumatology. 

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great Thieves market another dx to consider for ? inflammatory arthritis swelling/stiffness post cold exposure Microgeodic Disease-digital swelling/pain likely from bone infarction 2/2 to cold induced vasospasm characteristic x ray/MRI findings on poster #ACR21 #meded
Adam J Brown @AdamJBrownMD( View Tweet )
Nov 08, 2021