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Dec 01, 2022

A UK study suggests the equivalent outcomes when patients with interstitial lung disease (ILD) associated with connective tissue disease (CTD) are treated with either intravenous rituximab (RTX) or cyclophosphamide (CTX), but with fewer adverse events with RTX. 

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How Underweight Women Can Reduce Hip Fracture Risk

Nov 28, 2022

How women can reduce the risk of hip fracture?  

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Open label trial compared arthroscopic repair to PT in 100 young pts w/ traumatic, MRI proven meniscal tear without knee OA. Outcomes at 24 months - both groups improvved and were not different between groups
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The disconnect between objective inflammatory response and PROs in AxSpA

Nov 23, 2022

The assessment of disease activity in AxSpA involves the use of objective inflammatory response (OIR) and patient reported outcomes (PROs). In clinics, a combination of OIR and PROs are used to measure disease activity and response to treatment. OIR includes measurements such as CRP and MRI

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Imaging in PMR

Nov 18, 2022

Despite the fact that polymyalgia rheumatica is the most prevalent inflammatory rheumatic disease in those over 65 years of age, progress in its diagnosis, monitoring and management have failed to garner momentum in decades past.

However, ACR22 has fostered significant promise for its future.

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van Nieuwland et al. Comparison US/PET/MRI in GCA. Good specificity but relatively low sensitivity for all. PET best for extra-cranial. MRI/US best for isolated cranial. @RheumNow #ACR22 Abstr#1617
Spinal lesions on MRI in axSpA is ~3% in patients with negative imaging in SIJ on MRI or X-ray. Agreement in >5/9 central readers. Frequency of spinal vertebral corner BME lesions was significantly higher these cases. Maksymovych Abs#2257 #ACR22 @RheumNow
ACR Best

ACR Best Abstracts - Day 2

Nov 13, 2022

Day two at ACR 2022 was full of great sessions on imaging, vasculitis, lupus, vasculitis, spondyloarthritis, COVID, pregnancy, microbiome, economics and more.

Here are the RheumNow faculty selections for #ACRbest abstracts today:

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Can Neural Networks Answer Important Diagnostic Dilemmas in Rheumatology?

Nov 13, 2022

An interesting study presented at ACR22 looked at whether neural networks can distinguish seropositive rheumatoid arthritis (RA+), seronegative RA (RA-), and psoriatic arthritis (PsA) using hand MRI data based on the structural inflammation patterns.

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De Craemer et al. Local vs Central reading of images. Rheumatologists overcall sacroiliitis on both plain films and MRI in ?AxSpA . ? some of this out of a desire to try something to help someone who is suffering @RheumNow #ACR22 Abstr#1255
Rech et al. 18 month results of ARIAA, 6 months abatacept in pre-RA, 1 year drug-free follow-up. 35% vs 65% developed RA. MRI response 57% vs 29%. @RheumNow #ACR22 Abstr#0530
Puzzle pieces

Where are we with treating Pre-Rheumatoid Arthritis?

The ability to prevent RA in individuals at risk is a holy grail in rheumatology. There is a long history dating back to the PROMPT trial of methotrexate and PRAIRIE trial of rituximab. Both otrials showed an effect, but it seemed more likely to be a delaying of RA than prevention or modulation

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Proposed Cancer Screening for Inflammatory Myositis Patients

Nov 12, 2022

Today's plenary session features a novel proposal on how and which patients with Idiopathic Inflammatory Myopathy (IIM) should be screened for cancer.  Abstract 0002 by Oldroyd et al, entitled "Cancer Screening Recommendations for Patients with Idiopathic Inflammatory Myopathy" took on this

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Good grief, no! Why not get a SPECT-CT and arthroscopy on them all as well? Less is more. I will grudgingly get a plain radiograph #ACR22
What's the role of MRI in #osteoarthritis? #ACR22 @RheumNow #acrreview
When referring to radiographs in #osteoarthritis, it can be better described as early, advanced or end-stage as it only shows the extent of joint damage accrued over time, not telling us much on the severity of disease - Dr. Scanzello #ACR22 @RheumNow
What's the clinical use of imaging in #osteoarthritis? 👉Useful in atypical presentations, NOT required for dx 👉Always consider the view (particularly knees) 👉No evidence in predicting response to non-surgical tx #ACR22 @RheumNow #acrreview
Medicare will cover #DXA testing for these diagnoses ⁦@RheumNow⁩ #acr22 #acrreview

AS, Lupus and Subclinical RA: What I'm looking forward to at ACR22

Nov 10, 2022

As we approach ACR22, there are many things to be excited about, especially with the reintroduction of in-person attendance. My attention this year is in research being presented in these three areas: ankylosing spondylitis; lupus management and treatment; and, subclinical RA.

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NEJM: Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis - 70yoM with 6-month history of dysphagia. Compression of the hypopharyx by large cervical osteophytes was seen in a videofluoroscopic swallowing study
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Does Fibromyalgia Need B12? (9.9.2022)

Sep 09, 2022

Can we predict the bad outcomes? Like when ITP evolves into SLE; or when psoriasis will develop arthritis; or if Sjogren's will develop lymphoma? Let's dive in and review these journal reports and this past week's news from

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Pirfenidone Potential in RA-Related Lung Disease

MedPage Today
Sep 07, 2022

Rheumatoid arthritis patients with existing interstitial lung disease (ILD) had less decline in lung function when receiving the antifibrotic agent pirfenidone (Esbriet) relative to placebo in a randomized trial, researchers reported here and in a simultaneous journal publication.

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The Great Unknowns (8.5.2022)

Aug 05, 2022

Dr. Jack Cush reviews the news, FDA approvals, journal articles from the past week on RheumNow; plus viewer questions. This week great hopes for vitamin D, the great unknows of CSA and the great big mess that is the gout.

  1. 521 clinically suspect arthralgia (CSA) pts were

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Supplemental Vitamin D Fails to Lower Fracture Risk

Aug 02, 2022

NEJM has published study results showing that vitamin D3 supplementation does not significantly lower fracture risk (vs. placebo) when used in generally healthy adults.

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Upadacitinib in non-radiographic Axial Spondyloarthritis

Aug 01, 2022

The janus kinase inhibitor, upadacitinib, has been shown to significantly improve the signs and symptoms of non-radiographic axial spondyloarthritis (nr-AxSpA), extending the efficacy of UPA beyond classic ankylosing spondylitis.

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