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Immunology

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Cytokine Inhibitor Lung Disease in Still's Linked to HLA-DRB1 Alleles

Dec 01, 2021

Pulmonary complications in the setting of Still's disease (juvenile and adult) has seldom but consistently been reported, including reports of pneumonitis, pulmonary hypertension and a severe or fatal lung disease, often associated with hypersensitivity to anticytokine therapy. A multicenter

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Are there people looking at steroid-sparing therapy as irAE treatment or prevention? @CCalabreseDO: are there ever #ACR21 irAE Study Group @RheumNow (also @NAbdelwahabMD @ReidMDMPH on stage) https://t.co/CLmNaLB68O
Nov 09, 2021
#ACR21 #Abstr1492 Could gut microbiome contribute to Anti-Ro+/autoimmunity in #lupus? Analyses of 125 stool samples from mother of children with neonatal lupus and/or heart block revealed its potential role in genetic-environment interaction @RheumNow https://t.co/FnJtZJSCRj https://t.co/ttRdP9NIrG
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 09, 2021
#ACR21 Ab#1681: ATI-450- MK2 Inhibitor ⭐️Downstream MK2 mediated inflamm drive of p38. ⭐️Hope this would avoid tachyphylaxis in p38 inhibitor meds ▶️Phase2a study in 19 pts: Well-tolerated (SEs: UTI, ventricular extrasystole), good 12 week data @Rheumnow https://t.co/6lo7zPJUpx
Nov 09, 2021
Prof. Cornelia Weyand wonderfully summarizes the mechanisms behind the premature immune #aging phenotype in #RheumatoidArthritis leading to tissue #Inflammation 🔸defect in mitoDNA repair 🔸expanded rough ER 🔸⬇ protein myristoylation @RheumNow #ACR21 #RheumTwitter https://t.co/8cyqLscctB
Nov 08, 2021
Did you know?🤔Immune #aging: 🔖Begins at 20y and accelerates at 50y 🔖Species-specific 🔖The older immune system is restructured (keep that in mind when diagnosing or treating these pts) 🔖Accelerated w/ chemotx, chronic infection etc. @RheumNow #ACR21 https://t.co/bgbN3VKMCw
Nov 08, 2021
#ACR21 Year in Review. Caielli et al. showed in some patients with #lupus, red blood cells retained their mitochondria (Mito+ RBCs) and their frequency correlated with disease activity and blood⬆️IFN @RheumNow https://t.co/ZixgAbOWJ0 https://t.co/hkTWE4m7Ph
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 08, 2021
#Abstr0002 #ACR21 What drives salt in saliva in #sjogren? A study suggested Bcell cytokines mediated the epithelial Na+ Channel disruption. A case for targeting Bcell to improve oral health @RheumNow https://t.co/Bx3kBpOIFX https://t.co/YYnC6UoMJY
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 08, 2021
⭐️AxSpA pts with decrease in oral microbial diversity ⭐️Immune response to oral/fecal microbes altered in AxSpA pts. ⭐️HLA-B27 associated ⬆️IgA coated microbes, may contribute to development of AxSpA Abs#0052https://t.co/NQgm0lpYJj#ACR21 @RheumNow

Robert B Chao, MD @doctorRBC( View Tweet )

Nov 08, 2021
Dr Preger report 9 novel aminoacyl tRNA synthetases in IIM patients. May these allow us to spare more patients biopsy? Abstr#0001 #ACR21 @RheumNow https://t.co/ikNXCEOeuj
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
apart from that, fibrosis is fascinating - as is the potential for a shared fibrotic pathway #ACR21 Antifibrotics session @RheumNow https://t.co/FXbhBx9sJ1
Nov 08, 2021
BAFF & APRIL support B cell development, diff, survival. ALPN-303: Antagonist of both BAFF & APRIL 💠⬇️B cell fxn & Ab production,⬇️Plasma cells 💠⬇️UProt, dsDNA, renal immune complexes (mouse model) 💠Pending human studieshttps://t.co/kzVpUDuNWs#ACR21 Abst#1429 @RheumNow

Pedro Castillo @_Castillo_Pedro( View Tweet )

Nov 08, 2021
Novel way to treat inflammatory arthritis! A bioengineered probiotic bacterium, L. reuteri (LrS235) was found effective to reduce inflammation and clinical signs of inflammation in rats with inflammatory arthritis. Abst # 1707 #ACR21 @rheumnow https://t.co/UC28yRlGYP
TheDaoIndex @KDAO2011( View Tweet )
Nov 08, 2021
Wager question that cemented the winners: @UTMB: ⭐️This monogenic disease can mimic Behcet's & occurs d/t mutat in TNFAIP3. ➡️Haploinsufficiency A20 Congrats to the winners & all contestants, including the top 2 finalists: @MGHrheumatology & @EmoryUniversity! #ACR21 @RheumNow https://t.co/LZqsBKiPL8
Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )
Nov 08, 2021
Anti-NETs antibodies in #COVID. 1️⃣ correlate➖ w/ SpO2/FiO2 ratio (IgG r=-0.17 IgM r=-0.30 2️⃣correlate➕ w/ ⬆️D-dimer (IgG r=0.33 IgM r=0.19 3️⃣ ⬆️ in pts requiring MV In a study of 328 pts. Probably driving complement activation! #ACR21 #Abst1430 @RheumNow https://t.co/2MCrLueTzN
Aurelie Najm @AurelieRheumo( View Tweet )
Nov 08, 2021
Wonderful interview @KDAO2011 and @alhkim with great learning points on #BCell #Immunology #ACR21 @RheumNow https://t.co/1292FNZanL

Akhil Sood MD @AkhilSoodMD( View Tweet )

Nov 08, 2021
#ACR21 Abs:#1429: ALPN-303: Dual BAFF/APRIL antagonist for SLE: ⭐️Encouraging immunomodulatory activity and efficacy in animal models. ⬇️ Plasma cells and Ig secretions in vitro & vivo ⭐️Well-tolerated in animals w/o adverse events 🔥Phase 1 study in healthy volunteers! @Rheumnow
Nov 08, 2021
ACR Best

ACR21 Best Abstracts - Day 2

Nov 07, 2021

The RheumNow faculty reporters have been scouring and reporting on the best abstracts from the ACR. Here is a sampling of their choice abstract presentations reported during ACR 2020 Day 2 (#ACRbest).

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Abst#0572: In US veterans w/ RA followed for 17 yrs, several cytokines+chemokines ⭐️Associated w/ ↑ risk of incident MACE independent of typical CVD RF & RA activity & ⭐️Predicted MACE even if in LDA/remission WOW! We need to do better @ CVD risk strat! #ACRBest @RheumNow https://t.co/J74rRa9EQE
Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )
Nov 07, 2021
⭐️RA pts w/ high adipokines (fat-secreted proteins) have lower rates of LDA + remission independent of b/l dz activity & BMI ⭐️↑ adipokines esp adiponectin, then more likely to need b/tsDMARD ➡️Adipokines may be prognostic biomarkers 4 refractory dz. Abst#0789 #ACR21 @RheumNow https://t.co/AFT22TzTFp
Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )
Nov 07, 2021
#ACR21 Ignaki Sanz makes the case that +++ AUTOANTIBODIES are integrally involved in #COVID19 immunopathogeneisis and may rise and fall w disease states- TBD what role they play in acute disease and #LongCovid @CCalabreseDO @VirusesImmunity @CleClinicMD #COVID19AB https://t.co/9dzCSh5V7R
Leonard Calabrese @LCalabreseDO( View Tweet )
Nov 06, 2021
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Opening Day Report

Nov 06, 2021

The opening of ACR2 Convergence was a hit for all who signed up and viewed in. The day included the presidential address by outgoing president Dr. David Karp (UT Southwestern) and a keynote talk and interview with Dr. Seema Yasmin (Stanford).



The Year in Review

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The future according to Dr. M Brenner? 👉Bioengineered cells to treat inflammation.👈 #BasicScience #YearInReview #ACR21 @rheumnow https://t.co/EgoYBEZgT0
TheDaoIndex @KDAO2011( View Tweet )
Nov 06, 2021
And I’m finally in the game!! On board for #ACR21 Enjoying hearing Virginia Pascal showing data on how opsonisation of red blood cells containing mitochondria results in the induction of Type I Interferon pathways Great paper here https://t.co/QWJLncYmC3 #ACRambassador

Chris Wincup @chriswincup( View Tweet )

Nov 06, 2021
#ACR21 - Dr. Virginia Pascual speaking on #PrecisionMedicine in Lupus. Mitochondria in RBC's will cause more disease activity in Lupus patients. Th groups that remove Mitochondria have less disease activity. Hope this takes us to #precisionmedicine soon!. #Looms4Lupus https://t.co/sMOmeJPMJX
Looms4Lupus @Looms4Lupus( View Tweet )
Nov 06, 2021
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