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Infection

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Herpes Zoster with JAK Inhibitors

Jan 31, 2023

JAK inhibitors are approved for several immune-mediated inflammatory diseases and carry a higher than usual risk of herpes zoster in certain conditions like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis.

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Simon Says “Don’t Do This” (1.27.2022)

Jan 27, 2023

Dr. Jack Cush reviews this week’s journal articles, focuses on studies that should not have been done and responds to viewer questions in Ask Cush Anything.




  1. "Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs

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JAMA: 13 million In US have latent TB (5-10% risk of getting active TB). Review of LTBI regimens: - Preferred: 4 mos Rifampin: better/safer of INH - Preferred: 3 mos of INH + rifapentine - more completers less SAE - ALternative: 6-9 mos of INHhttps://t.co/vZTmSKTFWu https://t.co/W7BraJs6yC
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Periprosthetic Joint Infections

Jan 23, 2023

Recent NEJM has reviewed arthroplasty-associated infection and periprosthetic joint infections (PJI), noting this is a rare event; notably these infections are caused by skin microorganisms introduced during arthroplasty surgery or may be seeded post-surgically, via hematogenously spread or

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2022 Rheumatology Year in Review

Jan 05, 2023

2022 was a year of recovery, discovery, and some losses.  While still dealing with the aftermath of COVID-19, rheumatologists were resilient as leaders for their patients and research in advancing rheumatologic care.

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COVID-19 Vaccine Responses in Rheumatic Disease Patients

Dec 16, 2022

Nature Reviews Rheumatology features a review of three notable papers that address the impact of SARS-CoV-2 vaccination on people with inflammatory rheumatic disease. 



Studies on the efficacy and safety of the COVID-19 vaccines, have shown rapid and strong development of immunity in

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During 2021–22 FLU season, 6% of hosp pedi-influenza pts had SARS-CoV-2 coinfection; these required more respiratory support. Risk of influenza death augmented by not recv vaccination (flu or covid), no antiviral Rx, comorbidities & coinfx w/COVID https://t.co/bfjeClHflW https://t.co/YTOEnNSQQN
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Low Dose IL-2 Therapy in Sjögren’s

Nov 29, 2022

There is a large, unmet need in treating Sjögren’s syndrome, yet a new randomized clinical trial has shown that low-dose interleukin 2 (LD-IL-2) was effective effective and well tolerated in patients with primary Sjögren’s syndrome (pSS), with evidence of restored immune balance.

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Broder et al. HCQ alone vs steroid alone as maintenance in ESKD due to SLE. HCQ less cardiac events, less infection. @RheumNow #ACR22 Abstr#0539 https://t.co/mb3Eof2Uiv https://t.co/3i3ZTY25ru
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Infections in pre-RA: a cause or a consequence?

Rheumatoid arthritis is known to be associated with a higher risk of infections. In abstract 0535, Porter and colleagues have assessed infection rates in the pre-RA and early RA phases as defined by antibiotics prescription and hospital admissions with an infection main diagnostic code in the UK

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GLORIA trial showing low-dose addon pred in older patients with RA showing modest benefit (including reduction in damage) balanced against increased AEs (mostly infection); NNH 9.5! @RheumNow #ACR22 #yearinreview #ACRBest
Abstr #0083 COVID-19 vaccine use & hesitancy among rheum pts - 34% expressed concern for safety of primary vaccine - 39% did not get booster due to not being told by physician - We need to ensure pts up to date w/ vaccine including boosterhttps://t.co/y1vV7wbbpQ@RheumNow #ACR22 https://t.co/gcR2yOftjq
Wonderful slide by Dr. Sarah McCoy on #Sjogrens #ACR22 @RheumNow Broad differential for these patients when they present in clinic: 📍Ask about: 🚬 habits 💊 meds 🍬 🩻history: #diabetes, past radiation exposure 🦠 infection (#HIV, #HCV) 🩸 #vitamin deficiency https://t.co/6Qo23lWBs4
Opportunistic Infections with JAK inhibitors in RA Winthrop and colleagues have reviewed the occurrence of OIs associated with the use of JAK inhibitors in patients with RA, showing that Herpez zoster (HZ) was the most common OI reported.https://t.co/CtFcnHiWKS https://t.co/qKU51vLxaP
2022 EULAR Recommendations for Screening and Prophylaxis of Chronic and Opportunistic Infections A EULAR Task force has developed recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with AIIRD.https://t.co/VrdNggfMfG https://t.co/WARs0YJLZs
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Opportunistic Infections with JAK inhibitors in RA

Nov 07, 2022

Winthrop and colleagues have reviewd the occurrence of opportunistic infections (OIs) associated with the use of Janus kinase (JAK) inhibitors in patients with rheumatoid arthritis (RA), showing that Herpez zoster (HZ) was the most common OI reported with JAK inhibitors in clinical trials,

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2022 EULAR Recommendations for Screening and Prophylaxis of Chronic and Opportunistic Infections

Nov 07, 2022

A EULAR Task force has developed recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD).

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Women with Rheumatic Disease (11.4.2022)

Nov 04, 2022

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.  New regulatory decisions about JAK inhibitors and why do women with rheumatic diseases have unfair outcomes?




  1. Population study shows among vaccinated gout pts, COVID breakthrough

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Undiagnosed RA During the Pandemic

EurekAlert!
Nov 04, 2022

The number of new diagnoses of rheumatoid arthritis fell by 20% in the first year of the COVID-19 pandemic, new research suggests.

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Infections & Lupus (10.28.2022)

Oct 28, 2022

Dr. Jack Cush discusses the news and journal reports from the past week on RheumNow. This week more lupus nephritis, more drug induced lupus and more lupus infections that may kill. 

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Infection: a Leading Cause of Death in Lupus

Oct 27, 2022

 Analysis of a national database of hospital discharges from Spain shows that infections accounted for 25% of lupus deaths, making infection the most common cause of death in SLE.



Study identified SLE patients from the Spanish Hospital Discharge Database and recorded the frequency of

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ACR Award Winners (10.21.2022)

Oct 21, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Highlighted discussion of implantable stimulators, urine proteomics and gut-immune responses to Prevotella in RA.




  1. Vaccination Cut Long COVID Risk for Rheum Patients Patients with

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Vaccination Cut Long COVID Risk for Rheum Patients

MedPage Today
Oct 20, 2022

Patients with rheumatologic conditions who developed breakthrough COVID-19 infection after vaccination were less likely to suffer long-term symptoms than unvaccinated but otherwise similar patients, researchers said.

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Prevotella Immune Response in Both Pre-Clinical & Established RA

EurekAlert! and Jack Cush
Oct 19, 2022

In a recent analysis published in Arthritis & Rheumatology, people at risk for rheumatoid arthritis (RA) and those with the disease had elevated blood levels of antibodies against a Prevotella copri (Pc). 

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2 HIV+ pts with HLH (MAS) successfully Rx w/ JAKi - ruxolitinib. Both had high fevers, severe pancytopenia, hypofibrinogenemia, hypertriglyceridemia, & increased ferritin, BMBx Hemophagocytosis, splenomegaly. https://t.co/yGs7e4Ftgp https://t.co/cv9NX31bZr

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