Skip to main content

Labs/Biomarkers

IL-35 (blood and urine) is elevated in #SLE pts with nephritis. Small study of 42 SLE pts serum IL-35 had 90% sensitivity & 65% specificity while urine IL-35 had 86.4% sensitivity and 75% specificity to establish the diagnosis of LN https://t.co/pK1rVCQQr9

Dr. John Cush @RheumNow( View Tweet )

Nov 29, 2021
keystone

RheumNow Podcast - 60/40/20 Interview with Dr. Ed Keystone

Nov 26, 2021

Dr. Jack Cush interviews Professor Edward Keystone, MD (University of Toronto) on the origins and science behind the 60/40/20 benchmark and outcomes in rheumatoid arthritis.


Read Article
Autoinflammatory: PAH in AOSD, VEXAS, JAKi in Still's, Role of labs in infections vs. flares Drs.Cush, Yusof, Mehta, Petryna and Tate review autoinflammatory data presented at #ACR21. @Yuz6Yusof @bella_mehta @DrPetryna @uptoTate https://t.co/oeAprkSBWZ https://t.co/1g9yRRFJqf
Dr. John Cush @RheumNow( View Tweet )
Nov 24, 2021
Giant-Cell_Vasculitis.jpg

Top vasculitis takeaways from ACR 2021

There were several hot topics at ACR21. Here I concentrate on top abstracts in vasculitis. 

Read Article
RheumNow Podcast square

RheumNow Podcast - ACR 2021 Rehash (the good stuff..)

Nov 12, 2021

The ACR 2021 meeting has concluded. Dr. Jack Cush recounts a few more great abstracts from this past week’s virtual meeting.

Read Article
heel enthesitis spur calcaneal

Predicting RA, and Treatment of Subclinical Arthritis

Identifying patients that will develop RA in situations of seropositivity without overt clinical arthritis or identifying patients with undifferentiated oligo/polyarthritis that will develop RA remains a challenge in the field of rheumatology. 

Read Article
#ACR21 #Abstr1908 Potential prognostic biomarker for lymphoma in #sjogren. ISG15 (IFN-I) expression was consistently ⬆️in pts with lymphoma vs none, both in blood and salivary gland biopsy. Work needed re: relation to other markers, ethnicity @RheumNow https://t.co/8VYYEXpXSw https://t.co/ZIkpx5kUfu
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 09, 2021
SLE: Belimumab + standard rx significantly⬇️risk of severe flares vs placebo. Greatest in those with: 🔹+dsDNA 🔹low C3 or C4 🔹SLICC/ACR Damage index of 0 (argument for early treatment!)https://t.co/UcGXEklqwJ#ACR21 Abst#1295 @RheumNow

Pedro Castillo @_Castillo_Pedro( View Tweet )

Nov 08, 2021
AxSpA: Geographic Prevalence Association with HLA-B27: Dr. Rachel Tate ( @uptoTate ) Dr. Rachel Tate discusses abstract #0368 presented at the #ACR21 annual meeting.https://t.co/CnIjlWuKjZ https://t.co/vytIdK9CCo
Dr. John Cush @RheumNow( View Tweet )
Nov 08, 2021
Knowledge Bowl at #ACR21 ⭐️In a suspected PAN case, you order a peripheral smear to look for this potential etiology, ➡️Hairy cells @RheumNow

Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )

Nov 08, 2021
Dr Stewart @TonyMerriman2 report in 16,000 patients that repeat serum urate testing not superior to single measure in predicting incident gout over 9 years. Makes sense in general, maybe different in those with medication changes etc? Abstr#1449 #ACR21 @RheumNow https://t.co/69NofMNuB8
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
Guselkumab treatment of PsA improved Hgb levels and ⬇️ incidence of anemia ⭐️Anemia resolution associated with improved clinical status #ACR21 #ACRBest Abs#1331 @RheumNow https://t.co/nbG7DpMDaR https://t.co/rxWsVfNqed
Robert B Chao, MD @doctorRBC( View Tweet )
Nov 08, 2021
Lab work

Infection or Disease Flare: What Tools Can Help Differentiate?

Nov 08, 2021

Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need. 

Read Article
Knowledge Bowl at #ACR21 ⭐️Which HLA allele confers an increased risk for anterior uveitis and inflammatory sacroillitis? ➡️HLA-B27 @RheumNow

Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )

Nov 08, 2021
Knowledge Bowl at #ACR21 ⭐️This HLA allele can be seen in a certain vasculitis where panuveitis is a possibility and has a venulitis predilection ➡️HLA B51 @RheumNow

Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )

Nov 08, 2021
Peripheral and axSpA pts with low Vitamin D levels (<30) had worse disease activity and functional impairment (BASDAI, ASDAS, BASFI) compared to pts with normal Vit D levels. Abs#1316 #ACR21 @RheumNow https://t.co/ulIqOAnWtp https://t.co/aMQaTpduJK
Robert B Chao, MD @doctorRBC( View Tweet )
Nov 08, 2021
#ACR21 Abs#1225: B/L Extracell Matrix Biomarkers predict ABA response in MTX-naive, +ACPA early RA ⭐️ECM biomarkers predict SDAI remission or DAS28 w ABA+MTX vs PBO+MTX. ⭐️⬆️CTX1 biomarker predicts efficacy endpts for ABA+MTXhttps://t.co/7wHQefb5D4 @Rheumnow
Nov 08, 2021
#ACR21 #Abstr1011 Can we differentiate NEMO-deleted exon 5 autoinflammatory syndrome (NEMO-NDAS) vs CANDLE? Bioinformatics to mask the IKBKG pseudogene is promising and identified IL-6, 8,18, IFN-I and TNF-induced cell death as future targets @RheumNow https://t.co/tR2PNymMVn https://t.co/yCKHQx6R3E
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 08, 2021
Abst 0789 Baker & colleagues examined adipokine levels in association with disease activity in RA patients - Patients with high levels of adipokines less likely to achieve low disease activity & remission - These patients more likely to escalate to b/tsDMARDs #ACR21 @RheumNow https://t.co/1xlO4W9q9v
Akhil Sood MD @AkhilSoodMD( View Tweet )
Nov 07, 2021
#ACR21 #pedsrheum juvenile localized scleroderma Polypositive profile 3 or more autos correlated with more severe skin score, more activity https://t.co/vVXV4jjLvG
Dr. Laura Lewandowski @LauraLewMad11( View Tweet )
Nov 07, 2021
TOFA Post hoc analysis on 2000pts: ⬆️ Paraoxonase PON1 activity associated w/ ⬇ risk of malignancies (not NMSC) in RA pts treated w/ TOFA, Adj on RA duration, age, and smoking. A promising biomarker! #Abst980 @RheumNow #ACR21 https://t.co/fOILnAyDN9
Aurelie Najm @AurelieRheumo( View Tweet )
Nov 07, 2021
Awesome presentation today from Dr. Cristina Ruiz-Romero on lipidomic profiles in RA vs PsA. Using mass spectrometry, found differences in both synovial bx and fluid. Potentially useful lipid markers, more studies to follow. #ACR21 #ACRBest Abst#0946 @RheumNow https://t.co/KmWCPKijSx
Pedro Castillo @_Castillo_Pedro( View Tweet )
Nov 07, 2021
Getting closer to personalised medicine in AS, ECM-mediated biomarkers may help predict response to Adalimumab in AS. The biomarkers C1M, C6M and PRO-C4 were lower in responders to adalimumab treatment after 24 weeks @RheumNow #ACR21 Abst#0915 https://t.co/K2YxPvUAwu https://t.co/w9kcBSFeG9
Dr. Antoni Chan @synovialjoints( View Tweet )
Nov 07, 2021
Soluble urinary ALCAM previously shown as potential biomarker for LN. Further study showing urinary ALCAM trended with changes in renal-SLEDAI and UPCr. #ACR21 Abst#3053 @RheumNow https://t.co/IqVJej7yda

Pedro Castillo @_Castillo_Pedro( View Tweet )

Nov 07, 2021
Abst#0788 #ACR21. Forgot to measure vitamin D? ▶️ Red cell distribution width (RDW) inversely correlates w vit D 25(OH) levels prior to MTX ⭐️ RDW ⬆️ after starting MTX, no longer correlateshttps://t.co/b5EPDmGE18 @Rheumnow https://t.co/cNN14ErOmF
Nov 07, 2021
×