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Osteoarthritis

Steroid injections worsen knee arthritis Two studies comparing injections commonly used to relieve the pain of knee osteoarthritis found that corticosteroid injections were associated with the progression of the disease. https://t.co/pAeU3IzZfx https://t.co/rgJeHM5t62
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How Underweight Women Can Reduce Hip Fracture Risk

EurekAlert!
Nov 28, 2022

How women can reduce the risk of hip fracture?  

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Open label trial compared arthroscopic repair to PT in 100 young pts w/ traumatic, MRI proven meniscal tear without knee OA. Outcomes at 24 months - both groups improvved and were not different between groups https://t.co/rbrUAWuKRa https://t.co/OaNTssAvCG
How much does diet and exercise help in knee osteoarthritis? Pragmatic RCT (WE-CAN), n=823 a diet & exercise intervention program led to: - 10kg weight loss - some significant pain improvements We need to fund diet & exercise programs for OA patients! ABST1675 #ACR22 @RheumNow https://t.co/Ctm8ZoRF3o
WE-CAN pragmatic RCT on community-dwelling ♂️&♀️ >/=50y w/ knee #osteoarthritis & obesity: 💠Diet + exercise = significant weight ⬇️and ☑️WOMAC pain score, WOMAC function, 6min walk distance & SF-36 HRQoL 🍽️+🚶‍♀️in OA? = Yes we can! #ACR22 @RheumNow @rheumarhyme https://t.co/Ty2boH52HC
Ab1675 #ACR22 WE-CAN - Knee OA 823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E) Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO) 20% more likely: clinically meaningful improve Improved BMI, 6MW, HRQoL, activity Pain Rx, depression: no change @RheumNow https://t.co/Su2g4Z38FV
Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl
Plenary session III: Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life. Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV
Messier et al. WE-CAN pragmatic trial of diet and exercise (vs attention control) in knee OA with high BMI. Significant improvement in pain, walk distance, SF-36 with corresponding reduction in body weight @RheumNow #ACR22 Abstr#1675 https://t.co/uSSzx4u2sp https://t.co/upnIVecRjv
In overweight and obese patients with knee OA, 18-months of diet and exercise delivered in community settings significantly reduced WOMAC knee pain (-0.6) compared to an attention control group. Messier S Abs#1675 https://t.co/GvPCGz0NMN #ACR22 @RheumNow https://t.co/yWAwGwunzT
Promising data on denosumab in erosive OA Phase 2 study - less erosive progression, more symptom improvement Abs# L05 @RheumNow #ACR22 https://t.co/9Fg3r02ZQG
Wittoek et al. 48-week RCT of Denosumab in erosive hand OA. Prevents structural progression! @RheumNow #ACR22 Abstr#L05 #ACRbest https://t.co/CI6VBERSmn https://t.co/OszJkGeJF7
L05 #ACR22 High-dose Denosumab in Erosive Hand OA 48Wk, Double-blind PBO Phase 2 100 patients GUSS change higher in DEN v PBO at w24, incr at w48 New erosions lower in DEN w48 (2% v 7%, OR 0.23, p<0.001) Open label extension w improvement to baseline @RheumNow https://t.co/X6MF9q2bKj
Walrabenstein et al. RCT of 16-week triple intervention - plant-based diet, exercise, stress management - vs usual care in OA. It works, but we don't know which component, or if Hawthorn effect @RheumNow #ACR22 Abstr#1644 https://t.co/p74Ptd8bZ2 https://t.co/EOg7RxRmO7
Denosumab in erosive hand OA. 12-weekly dosing, primary end-point at 24 weeks. @RheumNow #ACR22 #LateBreaking
Yazici et al. IA Lorecivivint in Knee OA. 56 week DB-RCT of single injection at time 0. Didn't work. Not for primary endpoint (Pain NRS) or any PRO. @RheumNow #ACR22 Abstr#1639 https://t.co/66KyJW1zVz
Utamawatin et al. DB-RCT of Triamcinolone 10mg vs 40mg for knee OA. No difference! Wonder if 10mg would be better than saline? @RheumNow #ACR22 Abstr#1890 https://t.co/vcKze7mSf4 https://t.co/ErEkmUN0Wp
Maksymowych et al. RCT ofAdalimumab for knee OA!? it doesn't work. @RheumNow #ACR22 Abstr#1891 https://t.co/pfPVJ9A1Ex https://t.co/X7sLEaqGvT
Yazici et al. RCT of IA Lorecivivint for moderate/severe knee OA. CLK/DYRK inhibitor. No effect seen. @RheumNow #ACR22 Abstr#1899 https://t.co/XGQrMmNnSR https://t.co/rSJrT6Hms6
Bihlet et al. Anti-histamines may reduce structural progression of knee OA. Post-hoc analysis of 2 trials @RheumNow #ACR22 Abstr#1893 https://t.co/RrrelHDz75 https://t.co/Sf7RpjjAaN
Shanahan et al. RCT of Genicular nerve block for knee OA. It works but temporary, with loss of effect by week 12. @RheumNow #ACR22 Abstr#1892 https://t.co/VySjBGrVeR https://t.co/JNKQeOVB6z
Ab0577 #ACR22 Sao Paulo Aging & Health (SPAH) Radius 1/3 BMD enhance fx risk estimates when combined w/ spine (RR 1.4, p=0.03) For radius+hip or radius+spine/hip, radius DEXA is non-significant - only hip predicted fx Use radius BMD when hip unattainable- THA/severe OA @Rheumnow
QD Clinic - How to Treat Erosive OA (abstract #L05) 61yoWM with bilateral pain/swelling in DIPs. Labs normal, seronegative and Xrays shows evidence of DIP erosive OA. But what works in EOA? #ACR22 https://t.co/tbIoTg6kxA https://t.co/YcW7TON0En
What's the role of MRI in #osteoarthritis? #ACR22 @RheumNow #acrreview https://t.co/uZEzUSLo88
When referring to radiographs in #osteoarthritis, it can be better described as early, advanced or end-stage as it only shows the extent of joint damage accrued over time, not telling us much on the severity of disease - Dr. Scanzello #ACR22 @RheumNow https://t.co/m7Vdmu6KM6
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