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ACR20 Jefferson Memorial

ACR Urges CMS to Reconsider Copay Assistant Programs in CMS Proposed Rule

Feb 01, 2023

The Health and Human Services Notice of Benefit and Payment Parameters proposed rule for 2024 does not revise policies related to copay assistance and patient deductibles.



 The American College of Rheumatology (ACR) today submitted comments to Centers for Medicare and Medicaid

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Hope for Biologic Treatment of Hidradenitis Suppurativa

Feb 01, 2023

A meta-analysis of trials using biologics [adalimumab (ADA), ustekinumab (UST) and secukinumab (SEC)] in the the management of hidradenitis suppurativa (HS) suggests promising results, but more controlled, rigorous studies are needed.



While only adalimumab is currently FDA approved

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Herpes Zoster with JAK Inhibitors

Jan 31, 2023

JAK inhibitors are approved for several immune-mediated inflammatory diseases and carry a higher than usual risk of herpes zoster in certain conditions like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis.

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Women at high risk of fracture remain untreated for osteoporosis

EurekAlert!
Jan 30, 2023

An estimated 100,000 to 120,000 fragility fractures occur annually in the Netherlands, the equivalent of at least 11 broken bones per hour. The cause is osteoporosis, a disease in which the skeleton becomes weak and fragile, leading to potentially devastating fractures that result in

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Rheumatic Disease - IBD Overlap

MedPage Today
Jan 26, 2023

Nearly one in 10 patients with inflammatory bowel disease (IBD) also have rheumatologic disorders, meaning that specialists have to talk to each other to develop a treatment plan that works for both conditions, a researcher suggested.



Of 228 IBD patients treated in the clinic, 9.2%

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AI Passes U.S. Medical Licensing Exam

MedPage Today
Jan 26, 2023

Two artificial intelligence (AI) programs -- including ChatGPT -- have passed the U.S. Medical Licensing Examination (USMLE), according to two recent papers.



The papers highlighted different approaches to using large language models to take the USMLE, which is comprised of three exams

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VEXAS may be more common than expected

Jan 25, 2023

A great study of a recently described rheumatologic/hematologic disorder VEXAS (vacuoles, E1-ubiquitin-activating enzyme, X-linked, autoinflammatory, somatic) syndrome recently appeared in JAMA, describing the frequency and presentations of UBA1 variant. 

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Blood Test Identifies Osteoarthritis Progression

EurekAlert!
Jan 25, 2023

A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies.



The test relies on a biomarker and fills an important void in medical research for

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Variable Pregnancy Outcomes with Belimumab in SLE

Jan 24, 2023

An analysis of the belimumab clinical trials, the Belimumab Pregnancy Registry (BPR), and postmarketing/spontaneous reports looked at outcomes in pregnant systemic lupus erythematosus (SLE) exposed to belimumab reported there are few pregnancies and confounding disease and comorbidity factors

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Periprosthetic Joint Infections

Jan 23, 2023

Recent NEJM has reviewed arthroplasty-associated infection and periprosthetic joint infections (PJI), noting this is a rare event; notably these infections are caused by skin microorganisms introduced during arthroplasty surgery or may be seeded post-surgically, via hematogenously spread or

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JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure?

Jan 23, 2023

Data from 17 international registries (JAK-pot collaboration) suggest that for Rheumatoid arthritis (RA) patients failing their first janus kinase inhibitor (JAKi), it did not matter if they were cycled to another JAKi or switched to a biologic disease-modifying antirheumatic drug (bDMARD).

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Burden of BMI on Costs of Musculoskeletal Diseases

Jan 23, 2023

A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.



In this cross-sectional study of 192 countries and territories, 7.3 million years lived with disability and $180.7 billion

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PsA Til Death Do Us Part (1.20.2023)

Jan 20, 2023

Dr. Jack Cush reviews the highlights from the past week on RheumNow.com.

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AS, but not PsA, has Increased Mortality Risk

Jan 19, 2023

Inflammatory disorders are often accompanied by an increased mortality risk, either from secondary malignancy, infection or cardiovascular disease. A recent meta-analysis showed a significantly increased risk of overall mortality in ankylosing spondylitis (AS) but not psoriatic arthritis (PsA

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Phase III Trials Back Bimekizumab for Spondyloarthritis

Medpage Today
Jan 19, 2023

Bimekizumab, an investigational biologic drug targeting interleukin (IL)-17A/F, appeared highly effective in patients with axial spondyloarthritis (axSpA), researchers said.

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Poorer health outcomes for at-risk patients with fractures

Jan 18, 2023

People at high risk of fracture who also have complex or multiple chronic medical conditions are less likely to receive treatment for the underlying osteoporosis and also have poorer health outcomes, according to a new study from the Garvan Institute of Medical Research.  



These

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Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation

Jan 16, 2023

A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib). 

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RA Disease Activity and Alcohol Use

Jan 12, 2023

Despite its well known toxicities, alcohol is known to be antiinflammatory. The effects of alcohol use in rheumatoid arthritis (RA) is less known, but a recent study suggests that alcohol consumption was dose-dependently associated with lower disease activity and higher health-related quality of

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Worse Birth Outcomes in RA and SLE

Jan 11, 2023

A population-based retrospective cohort study patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and their infants demonstrated significant adverse pregnancy outcome, particularly the infants of women with SLE. This included maternal/infant rehospitalization,

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Bimekizumab in Active Psoriatic Arthritis - BE COMPLETE study

Jan 11, 2023

BE COMPLETE is published, showing that bimekizumab (BMK), a selective dual inhibitor of interleukin (IL)-17F and IL-17A, results in superior improvement in both skin and joint outcomes in psoriatic arthritis (PsA) patients who have previously failed treatment with a tumour necrosis factor-α (

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ACP Guidelines on Fracture Prevention in at-risk Adults

Jan 09, 2023

The American College of Physicians (ACP) has updated its 2017 recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults. The full document and guideline can be found in the Annals of Internal Medicine. This guideline is the

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Cannabis Use for Pain is Common

Jan 09, 2023

In states with legalized medical cannabis use, 3 in 10 persons are using cannabis to manage their pain.

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2022 Memorium

Jan 06, 2023

Sadly, too many of our rheumatology colleagues passed on in 2022. Here is an (incomplete) list of notable brethren, mentors, do-gooders and great rheumatologists:

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2022 Rheumatology Year in Review (1-6-2023)

Jan 06, 2023

Dr. Jack Cush reviews the best of 2022 in Rheumatology - highlights on new drug indications, breakthrough lupus therapies, new biosimilars and the multivitamin letdown.

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2022 Rheumatology Year in Review

Jan 05, 2023

2022 was a year of recovery, discovery, and some losses.  While still dealing with the aftermath of COVID-19, rheumatologists were resilient as leaders for their patients and research in advancing rheumatologic care.

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