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Pregnancy

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Methotrexate Monitoring (5.13.2022)

May 13, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.




  1. Risk factors for readmission among 132,400 #SLE hospitalizatiions included

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Three (3) Worst Drugs to use in #Lupus patients who want to be pregnant (MTX, MMF, CTX) #UTSWSLE2022 https://t.co/YBeLTuRLO1
Dr. John Cush @RheumNow( View Tweet )
May 07, 2022
Algorithmic approach to SLE and assessing/treating early pregnancy. #UTSWSLE2022 https://t.co/692el4R9sZ
Dr. John Cush @RheumNow( View Tweet )
May 07, 2022
Adverse pregnancy outcomes and Risks in #SLE. (Dr. Eliza Chakravarty - OMRF) #UTSWSLE2022 https://t.co/HqscJD2m96
Dr. John Cush @RheumNow( View Tweet )
May 07, 2022
Nearly 40% of all #SLE pregnancies are unplanned - hence, contraception (unused in 73%) and education are paramount in management of women w/ SLE. (Dr. Lisa Sammaritano- HSS) #UTSWSLE2022 https://t.co/ooryrW9GGn
Dr. John Cush @RheumNow( View Tweet )
May 07, 2022
Danish case-control registry of 491,274 women shows Psoriasis assoc w/ increased risk of ectopic pregnancy (EP) (OR 1.34), highest in women w/ moderate-to-severe psoriasis (OR 2.77). EP risk was 2.5x higher for women w/ mod--severe PSO https://t.co/vUtNEMDOhr

Dr. John Cush @RheumNow( View Tweet )

May 06, 2022
Canadian study of 6012 Pregnancies w/ +COVID-19 PCR test shows Preg pts increased risk of hospitalization (RR 2.65) & ICU adm (RR 5.46) vs gen population and higher risk of preterm birth vs preg women without COVID (RR 1.63) https://t.co/6UAaa0Jf8j https://t.co/aLQbxZArmq
Dr. John Cush @RheumNow( View Tweet )
May 05, 2022
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$30 Billion and Counting (4.29.2022)

Apr 29, 2022

Dr. Jack Cush reviews the news and journal reports and takes viewer questions this week.

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Pregnancy outcomes in systemic sclerosis (SSc) studied in 154 pregnancies from SSc, SLE, APS, & controls (2008 to 2019). Adverse Preg Outcomes APO significantly higher in SSc vs HC (61% vs 10%) w/ more miscarriages, preeclampsia, SGA & preterm births https://t.co/P3uksmJy6V https://t.co/nTtgwjdGgL
Dr. John Cush @RheumNow( View Tweet )
Apr 28, 2022
UK drug safety warning, observational data 2700 pregnancies, 1st trimester pregabalin (Lyrica) use was assoc w/ higher rate of congenital malformations (5.9 vs 4.1%). US PI label says Lyrica use in Pregnancy "May cause fetal harm". https://t.co/GdIitpe8KW

Dr. John Cush @RheumNow( View Tweet )

Apr 20, 2022
Steroids associated with adverse events during pregnancy ⁦@UmaMahadevanIBD⁩ ⁦@MayoClinicGIHep⁩ https://t.co/VR5CZUH1S7
Edward Loftus @EdwardLoftus2( View Tweet )
Apr 05, 2022
JAMA reports another study showing safety of COVID-19 vaccination during pregnancy with no incr in adverse pregnancy outcomes. Scand study of 157,521 births - 0.7%, 8.3%, 9.1% of were vaxD during 1st, 2nd, 3rd trimesters https://t.co/dZuabwr1Sf https://t.co/CtzMoEV1Ee
Dr. John Cush @RheumNow( View Tweet )
Mar 31, 2022
Canadian population study shows that mRNA COVID-19 vaccination DURING 2nd &3rd trimester of pregnancy did not increase rate of adverse peripartum outcomes (vs no vax or vax post-Preg). Comparison of 97 590 Preg vs 44 815 non-preg https://t.co/n7nWcoLw4S https://t.co/uiVOg5A1S8
Dr. John Cush @RheumNow( View Tweet )
Mar 31, 2022
ICYMI: Drugs for Pregnancy Hopefuls A Young Woman has uncontrolled RA, but wants to get pregnant. What do you chose? https://t.co/Sunx8RWRfM https://t.co/hsFNhVfwHd
Dr. John Cush @RheumNow( View Tweet )
Mar 26, 2022
98 axial SpA women with 335 pregnancies (279 live births) shows preterm birth ( (12.5 v 5.2%), preeclampsia(6.8 v 2.8%) & LBW (8.2 v 2.9%) more prevalent in axSpA, possibly due to incr disease activity during pregnancy & postpartum https://t.co/Bp8QjBXg2K https://t.co/j0xKVvSPIH
Dr. John Cush @RheumNow( View Tweet )
Mar 25, 2022
Healthy mother = healthy baby Pregnancy and neonatal complications linked to disease activity and inflammation @RheumNow #RNL2022 https://t.co/MeBnYnSfuK
Robert B Chao, MD @doctorRBC( View Tweet )
Mar 19, 2022
Retrospective cohort study of 338 pregnancies in IMID pts (~1/2 w/ IBD); 23% w/ biologic exposure had increase in post-partum flares (OR 3.44) & less being breastfeed (OR 0.44). Maternal and neonatal pregnancy outcomes were similar https://t.co/8pu2p8tK0s https://t.co/bVQx9La5j3
Dr. John Cush @RheumNow( View Tweet )
Mar 14, 2022
Postpartum maternal outcomes Study compared 202 RA pts to 596 non-RA controls. There was no difference in infection rates or transfusions, but RA was assoc w/ more preterm births (OR = 2.11). Steroids (41%) were associated with lower birthweight https://t.co/F8DKmEHh0M https://t.co/d4Jkb3huMy
Dr. John Cush @RheumNow( View Tweet )
Mar 04, 2022
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RheumNow Podcast - RWCS 2022 Roundup (2.19.2022)

Feb 21, 2022

Drs. Jack Cush and Artie Kavanaugh review the highlights of the RWCS (Rheumatology Winter Clinical Symposium) from Maui.


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MMWR study of shows 2 dose mRNA COVID vax during pregnancy was 61% effective preventing infant COVID. Among 176 infants hosp w/ COVID-19, 84% were born to mothers who were not vaccinated during pregnancy.https://t.co/mWgHHcL05u

Dr. John Cush @RheumNow( View Tweet )

Feb 17, 2022
ICYMI: MMWR reports >40,000 pregnant women who received COVID-19 vaccination during pregnancy- VAX not associated with preterm birth or small-for-gestational-age at birth overall compared with unvaccinated pregnant women. https://t.co/GtRMsNrFnn

Dr. John Cush @RheumNow( View Tweet )

Jan 30, 2022
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COVID-19 in Pregnant Rheumatic Women

Jan 10, 2022

The Global Rheumatology Alliance (GRA) has studied the outcomes of women with rheumatic disease who were pregnant at the time of infection with coronavirus disease 2019 (COVID-19).



The GRA database of rheumatic patients also includes information about pregnancy; further obstetric

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Best of 2021: Jack of All Subspecialties

Dec 31, 2021

It's great to be a rheumatologist, but boy, it's getting harder and harder. You have to be a jack of all trades. You have to be good at cardiovascular disease, osteoporosis, vaccination, inflammatory bowel disease - it just never ends. This and more, as Dr. Cush summarizes more than a dozen

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Best of 2021: Tofacitinib Safety Concerns

Dec 29, 2021

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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Best of 2021: Potential Birth Defects with Hydroxychloroquine

Dec 23, 2021

HCQ is one of the safest meds used in rheumatology, but new claims data suggests a small increase in the risk of malformations associated with first-trimester HCQ use. The March 2021 issue of the American Journal of Obstetrics and Gynecology studied the risk of major congenital malformations

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