Psoriatic Arthritis (PsA)

RheumNow Podcast – Good Time Charlie…. (10.16.20)

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Dr. Jack Cush sings the news and journal reports from the past week on RheumNow.com.

Tofacitinib and Thromboembolic Risk

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Mease and colleagues have reviewed the tofacitinib drug development and clinical trial data, finding the risk of venous (VTE) and arterial thromboembolism (ATE) to be low and augmented in patients with baseline cardiovascular abd VTE risk factors and those taking higher doses of tofacitinib (

RheumNow Podcast – Bad Disease & Bad Outcomes (10.9.20)

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Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com.

RheumNow Podcast – Function Follows Form (10.2.20)

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Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Regulatory approvals, update on global rheumatology alliance, smoking and psoriasis, gabapentin let down and defining difficult RA.

Low Risk of Latent TB with Secukinumab

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TB reactivation and latent tuberculosis infection (LTBI) are warned against with biologic agents, especially TNF inhibitors; yet clinical trial data now shows that the risk of LTBI with IL-17 inhibition via secukinumab is uncommon.

RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

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Dr. Jack Cush reviews the news and Journal articles from the past week on RheumNow.com.

EULAR Updated 2019 Recommendations for Psoriatic Arthritis Management

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In June 2020, we failed to report on the ARD publication updating the 2019 update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA) - these are presented below.

This guideline committee included 28

Ustekinumab Early Risk for Cardiovascular Events

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JAMA Dermatology reports a claims-based, case-time-controlled French study of 9290 psoriasis patients suggesting that ustekinumab initiation may be associated with an increased risk of acute coronary syndrome or stroke in high risk cardiovascular patients.

CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

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Research from Oxford University suggests a potential pathogenic role for the chemokine CXCR3 and clonally restricted CD8+ T cells in the pathogenesis of psoriatic arthritis (PsA) based studies of PsA synovial fluid samples obtained by arthrocentesis from 11 patients with large-joint oligo PsA

RheumNow Podcast – Lupus Delights (9.18.20)

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Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

Comorbidities Impact Disease Activity in Spondyloarthritis

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An analysis of a large population-based cohort of axial spondyloarthritis (axSpA) patients shows that comorbidities are common and are associated with higher disease activity and higher levels of functional impairment.

ACR 2020 Reproductive Guidelines - Lactation Guidance

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In this third excerpt from the ACR guidelines on managing reproductive health issues in rheumatic disease patients, we present recommendations regarding the use of glucocorticoids and guidance on lactation and medication use post-partum.

ACR 2020 Reproductive Guidelines - Medication Use with Pregnancy

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The American College of Rheumatology (ACR) has published guidelines to manage reproductive health issues in rheumatic disease (RMD) patients before, during and after pregnancy. In this second exerpt from their guidelines articles we present recommendations (and good clinical practice

ICYMI - 11 Pearls for Pregnancy Management in Rheumatoid Arthritis

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Rheumatoid arthritis affects women in their child-bearing years and many will face the issue of pregnancy and RA management at some point. Here are11 considerations for those managing RA patients who wish to become pregnant.

ACR 2020 Reproductive Guidelines - Contraception & Counseling

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The American College of Rheumatology established a guidelines committee that consisted of both patients, rheumatologists and maternal-fetal health experts. After a a systematic review of the medical literature regarding contraception, assisted reproductive technology, fertility preservation,

Treatment Options for Extraintestinal IBD

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Extraintestinal manifestations (EIMs) frequently accompany inflammatory bowel disease, often augmenting morbidity and mortality are associated with disease activity and may increase the need for surgery or treatment escalation.  A recent review in GUT details the treatment options for patients

Sleep, Fatigue and Depression in Psoriatic Arthritis

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Comorbidities are highly prevalent in psoriatic disease. A recent study in Arthritis Research & Therapy suggests a high prevalence of sleep disturbances, fatigue, and anxiety/depression in psoriatic arthritis (PsA) that is unrelated to skin disease musculoskeletal (MSK)

RheumNow Podcast – Rheum Lives Matter (8.28.20)

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Dr. Jack Cush reviews the news and journal articles from the past week. Of mice and men in cartilage, the efficacy of JAK inhibitors in patients who are having skin problems, nrAxSpa has its own diagnostic code, metformin, talking about Back Talk, plus so much more.

Durability of Total Shoulder Arthoplasty

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A systematic review of the outcomes of total shoulder replacements (TSR), humeral hemiarthroplasties, and reverse total shoulder replacements finds that approximately 90% of shoulder replacements last for longer than 10 years with good patient-reported outcomes.

This metanalysis