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Sjogrens

ICYMI: Clinical trials generally fail in Sjögren's syndrome; but now a study shows that a biologic B cell inhibitor, ianalumab, met its primary endpoint with a dose-related decrease in disease activity (measured by ESSDAI) at week 24.https://t.co/o2b1kwZ9QG https://t.co/ayaDlpl7DI
Dr. John Cush @RheumNow( View Tweet )
Jan 15, 2022
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Biologic Treatment of Primary Sjogrens with Ianalumab

Jan 11, 2022

Clinical trials generally fail in Sjögren's syndrome; but now a study shows that a biologic B cell inhibitor, ianalumab, met its primary endpoint with a dose-related decrease in disease activity (measured by ESSDAI) at week 24.



This was a phase II, dose-finding trial, aimed to assess

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Study of subcutaneous ianalumab in patients with primary Sjögren's syndrome met primary objective, showing dose-related decrease in disease activity (ESSDAI) at week 24: randomised, double-blind, placebo-controlled trial. https://t.co/NqdDWqpX2g https://t.co/PSxSRx28fM
The Lancet @TheLancet( View Tweet )
Jan 11, 2022
121 Sjögren’s pts dx w/ non-Hodgkin's lymphoma - 76% were MALT lymphoma (9% Diffuse Large B Cell, 7% Nodal Marginal Zone Lymphomas). MALT 10-yr survival was 79% MALT. Predictors were Cryoglobulinemia, focus score, ESSDAI at Dx https://t.co/EYsB06DU4s

Dr. John Cush @RheumNow( View Tweet )

Jan 03, 2022
fetus,defect,baby,malformation

Best of 2021: Potential Birth Defects with Hydroxychloroquine

Dec 23, 2021

HCQ is one of the safest meds used in rheumatology, but new claims data suggests a small increase in the risk of malformations associated with first-trimester HCQ use. The March 2021 issue of the American Journal of Obstetrics and Gynecology studied the risk of major congenital malformations

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Cancer,cells

Certain Cancers Increased with Autoimmune Diseases

Dec 16, 2021

Rheumatologists are well aware that inflammation and immune dysregulation are prime contributors to cancer risk, but do oncologists carry the same impressions? A large study from JAMA Oncology shows that patients with immune-mediated diseases (IMD) have an overall increased risk of cancer,

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#ACR21 #ACR2021 Sjogrens syndrome with pulmonary involvement guidelines 🚨Thread Alert 👉🏻Screen all patients for pulm inv. irrespective of symtopms ➡️ prevlance of lung involvement can be upto 65% 👉🏻Complete PFT includes ➡️ Spirometry➕ DLCO➕ PuseOximetry https://t.co/prFgQESRyF
EnvisionRheumat @ERheumat( View Tweet )
Nov 09, 2021
#ACR21 #Abstr1908 Potential prognostic biomarker for lymphoma in #sjogren. ISG15 (IFN-I) expression was consistently ⬆️in pts with lymphoma vs none, both in blood and salivary gland biopsy. Work needed re: relation to other markers, ethnicity @RheumNow https://t.co/8VYYEXpXSw https://t.co/ZIkpx5kUfu
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 09, 2021
#Abstr0002 #ACR21 What drives salt in saliva in #sjogren? A study suggested Bcell cytokines mediated the epithelial Na+ Channel disruption. A case for targeting Bcell to improve oral health @RheumNow https://t.co/Bx3kBpOIFX https://t.co/YYnC6UoMJY
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 08, 2021
Knowledge Bowl at #ACR21 ⭐️The first lung fibrosis described in Sjogren's with lung biopsy showing benign polyclonal lymphocytes and plasma cells with a risk for malignant transformation. ➡️Lymphocytic Interstitial Pneumonia @RheumNow

Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )

Nov 08, 2021
Lab work

Infection or Disease Flare: What Tools Can Help Differentiate?

Nov 08, 2021

Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need. 

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Does concomitant SJS affect tx effectiveness in RA? Abst#0839 suggest yes! ➡️RA+SjS have an inferior response to TNFi than RA patients w/o SjS BUT, RA/SJS pts w/ longer RA dz duration & ↑ DAS28 + HAQ-scores. What's your clinical experience with this? #ACR21 @Rheumnow https://t.co/TIc3raMOSJ
Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )
Nov 07, 2021
Are these pictures representative of a Sjogren's tongue or oral candidiasis? Comment below with your thoughts! #ACR21 #ClinicalPearls @RheumNow https://t.co/yGHA0pA7w0
Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )
Nov 07, 2021
Clinical Pearl at @ACR21 Is patchy tongue erythema + angular chelitis representative of Sjogren's or oral candidiasis? Beware: Oral candiasis is a mimic of Sjogren's tongue. Differentiate by asking if burning of tongue. If so, not Sjogren's -- start PO antifungal! @RheumNow https://t.co/FbdiX8PFKV
Meral K. El Ramahi, MD @MeralElRamahiMD( View Tweet )
Nov 07, 2021
#Abstr0002 #ACR21 What drives salt in saliva in #sjogren? A study suggested Bcell cytokines mediated the epithelial Na+ Channel disruption. A case for targeting Bcell to improve oral health @RheumNow https://t.co/Bx3kBpOIFX https://t.co/YYnC6UoMJY
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Nov 06, 2021
syringe,needle,vaccine

How Should Patients With Autoimmune Diseases Approach COVID Vaccination?

MedPage Today
Oct 25, 2021

Healthcare is a personal and individualized relationship between a provider and patient. Each patient is treated according to their particular symptoms and personal health characteristics. For this reason, the wide variability in patient responses to the same medical treatments must be

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RheumNow Podcast – I Wanna New Drug.V2 (9.24.2021)

Sep 23, 2021

Almost three years ago to the day, I did a podcast entitled, "I wanna new drug." As I go over this week's podcast, I want to say it again. I want a new drug safe enough to use during pregnancy, for PMR, for GVHD, and more. I'm going to cover these, and other topics including lupus, COVID

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Mumps,Parotid

CRESS – A New Composite Measure for Primary Sjögren's Syndrome

Aug 03, 2021

Randomized clinical trials in primary Sjögren's syndrome (pSS) are fraught with fault and inconclusive outcome measures, including the more recently developed EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI).  There's a new composite endpoint outcome for RCTs in pSS, called the Composite

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fetus,defect,baby,malformation

Potential Birth Defects with Hydroxychloroquine

Jul 13, 2021

Hydroxychloroquine (HCQ) is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.



While HCQ is generally considered safe in pregnancy, studies have been too few and

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Can Focus Score Predict Risk of Lymphoma in Sjogren's Patients?https://t.co/kBptqUx2XG https://t.co/8y1736Kj8T
Dr. John Cush @RheumNow( View Tweet )
Jun 22, 2021
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Do B-cell targeted therapies still have a place for the treatment of Sjogren’s?

B-cells play a major role in the pathogenesis of primary Sjogren’s syndrome (pSS) through antibody-dependent and antibody-independent functions, as well as evident by progression to B-cell malignancies/lymphoma. Hence, targeting B-cell is attractive. Despite efficacy of B-cell depleting therapy

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Do B-cell targeted therapies still have a place for the treatment of Sjogren’s?https://t.co/96sv3beMvG https://t.co/oabgmkAfGk
Dr. John Cush @RheumNow( View Tweet )
Jun 13, 2021
Can the Focus Score predict Lymphoma in Sjogren’s syndrome? by Dr. Eric Dein ( @ejdein1 )https://t.co/B5HN6ju3ru https://t.co/3MuXH66YqJ
Dr. John Cush @RheumNow( View Tweet )
Jun 09, 2021
Sjogren_syndrome_salivary%20bx%282%29.jpg

Can the Focus Score predict Lymphoma in Sjogren’s syndrome?

Jun 08, 2021

Patients with Sjogren’s syndrome are nearly 19 times more likely to develop lymphoma, so identifying factors that impact this risk development is a major goal in caring for this disorder. Many risk factors are established such as low C4, palpable purpura, parotid gland enlargement, and

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Do B-cell targeted therapies still have a place for the treatment of Sjogren’s? #EULAR2021https://t.co/96sv3beMvG https://t.co/EWKCA1KGsC
Dr. John Cush @RheumNow( View Tweet )
Jun 08, 2021
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