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Articles By Jack Cush, MD

COVID Test Antibody

Is It OK to Continue TNF Inhibitors with COVID-19 Infection?

By Jack Cush, MD
19 October 2021

Registry level data of patients with immune-mediated inflammatory diseases (IMIDs) diagnosed with COVID-19 should continue their TNF inhibitor (TNFi) therapy as such patients were less likely to experience adverse COVID-19 outcomes (compared to other immunomodulatory treatments).

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DPGN, lupus, nephritis, GN, glomerulonephritis, biopsy, kidney

NOBILITY: a Trial of Obinutuzumab in Proliferative Lupus Nephritis

By Jack Cush, MD
18 October 2021

B-cell depletion therapy with obinutuzumab, a type II anti-CD20 monoclonal antibody, in lupus nephritis patients was shown to be effective in in combination with standard lupus therapies.

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SI,sacroiliitis,erosion

TICOSPA - Does Treat to Target Work in Spondyloarthritis?

By Jack Cush, MD
18 October 2021

Tight-control or treat-to-target (T2T) strategy is advocated in several diseases, but the recent TICOSPA trial in axial spondyloarthritis (axSpA) showed that T2T was not superior to usual care (UC).

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steroid prednisone lab

Are You a High or Low Glucocorticoid Prescriber?

By Jack Cush, MD
15 October 2021

A recent analysis shows thta glucocorticoids (GCs), usually recommended for short-term use in rheumatoid arthritis (RA), are variably used by rheumatologists, and that provider preference is a strong predictors of long-term glucocorticoid use.

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RheumNow Podcast – Quackademia (10.15.2021)

By Jack Cush, MD
14 October 2021

Dr. Jack Cush reviews the FDA approvals, news and the latest journal articles from the past week on RheumNow.com.

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morbidity,covid,heart,lung,brain

2021 Update to EULAR Points on Immunomodulatory Use in COVID-19

By Jack Cush, MD
14 October 2021

EULAR has updated its recommendations (points to consider - PtC) for rheumatologists managing patients during COVID-19; now with 2 overarching principles and 12 PtC.

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Still’s Disease Following COVID-19 Vaccination

By Jack Cush, MD
14 October 2021

Both systemic onset juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease are acquired autoinflammatory disorders of uncertain etiology. Yet recent reports of AOSD onset and flare following COVID-19 vaccinations may have important mechanistic implications.

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Cancer Risk in Systemic Lupus Erythematosus

By Jack Cush, MD
13 October 2021

Bernatsky and colleagues have shown cancer risk factors in incident systemic lupus erythematosus (SLE). Researchers analyzed an SLE cohort of 1,668 patients, over an average of 9 years follow-up and found 65 cancers: 15 breast; 10 nonmelanoma skin; 7 lung; 6 hematologic; 6 prostate; 5 melanoma; 3 cervical; 3 renal; 2 each gastric, head and neck, and thyroid; and, 1 each rectal, sarcoma, thymoma, and uterine cancers.

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Psoriasis, arms, PsA

Abatacept After Ustekinumab Withdrawal in Active Plaque Psoriasis

By Jack Cush, MD
13 October 2021

A randomized controlled trial has shown that treatment of plaque psoriasis via costimulatory blockade ( CD28/B7) with abatacept did not prevent psoriasis relapse after withdrawal of ustekinumab.

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liver,hepaitis,pink,gb

Hepatitis B Reactivation with Rituximab and Abatacept

By Jack Cush, MD
12 October 2021

Hepatitis B reactivation is an uncommon complication of biologic therapy use. Now, a serologic study of  rheumatoid arthritis patients shows that HBV reactivation is seen with rituximab, and less so with abatacept, especially in patients without hepatitis B antibody (HBsAb) positivity.

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